Journal Article

DZNE-2026-00956

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Remote digital cognitive assessment in a trial-ready Alzheimer's disease cohort: A scalable approach for early intervention studies.

Aschenbrenner, A. J. ; Wilks, H. ; Welhaf, M. ; Katteri, S. ; Stout, S. H. ; Sliwinski, M. J. ; Benzinger, T. L. S. ; Gordon, B. ; Li, Y. ; Perrin, R. J. ; Renton, A. ; Wang, G. ; Xiong, C. ; van Dyck, C. H. ; Allegri, R. ; Brooks, W. S. ; Bechara, J. A. ; Jayadev, S. ; Levin, J.DZNE* ; Mummery, C. J. ; Sanchez-Valle, R. ; Aguillon, D. ; McDade, E. M. ; Bateman, R. J. ; Unit, D. I. A. N. T. (Collaboration Author) ; Hassenstab, J.

2026
Wiley Hoboken, NJ

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Please use a persistent id in citations: doi:10.1002/trc2.70311

Abstract: Early detection of cognitive decline in Alzheimer's disease (AD), particularly in preclinical stages, is critical for evaluating therapeutic interventions. Traditional cognitive assessments often require lengthy in-person visits, and may therefore limit scalability for younger, trial-ready populations for primary and secondary prevention studies. We evaluated the feasibility, reliability, and validity of high-frequency remote digital cognitive assessments in individuals with autosomal dominant AD (ADAD).One hundred twenty-three mutation carriers and non-carriers from the Dominantly Inherited Alzheimer Network Trials Unit from 20 international sites (Ages 19-66 years) completed remote assessments via personal smartphones, prompted four times daily for 7 days (≈ 3 minutes per session), and conventional in-clinic cognitive testing at baseline. Adherence, between-person reliability, test-retest reliability (intraclass correlation coefficients [ICCs]), construct validity (confirmatory factor analysis), and sensitivity to clinical disease progression were evaluated.Remote measures demonstrated excellent reliability (ICCs > 0.90 after just 10 sessions) and strong construct validity, with tasks loading onto memory, attention, and executive function domains. A composite of the remote tests slightly outperformed a traditional composite at separating mutation carriers from non-carriers. Average adherence to the study protocol was 42%, lower that observed in previous studies of older adults.High-frequency remote cognitive assessment is feasible, reliable, and valid in a relatively young international ADAD cohort. This approach offers substantial utility for clinical trials, including improved accessibility and enhanced reliability, supporting its integration into early-intervention studies.

Keyword(s): Alzheimer's disease ; clinical trials ; cognitive testing ; digital assessment ; remote monitoring

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Contributing Institute(s):

1. Clinical Neurodegeneration (AG Levin)
2. Clinical Research (Munich) (Clinical Research (Munich))

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

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Database coverage:
; ; Article Processing Charges ; Clarivate Analytics Master Journal List ; DEAL Wiley ; DOAJ Seal ; Emerging Sources Citation Index ; Fees ; IF < 5 ; JCR ; SCOPUS ; Web of Science Core Collection

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