Preprints

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2023-01-11
12:19
[DZNE-2023-00120] Preprint
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Prediction of Stroke Outcome in Mice Based on Non-Invasive MRI and Behavioral Testing
Prediction of post-stroke outcome using the degree of subacute deficit or magnetic resonance imaging metrics is well studied in humans. While mice are the most commonly used animals in pre-clinical stroke research, systematic analysis of outcome predictors is lacking.Methods Data from a total of 13 studies that included 45 minutes of middle cerebral artery occlusion on 148 mice were pooled. [...]

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2022-07-15
15:36
[DZNE-2022-01323] Preprint
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World War II cohorts and diabetes mellitus, coronary heart disease and cerebrovascular disease later in life: An observational cohort study based on German claims data
This study applied a data-driven approach to explore whether being born during or around World War II affects the risk of morbidity later in life.Methods Incident diagnoses were explored for diabetes (ICD-10 code E10-E14; 75,487 persons/12,905 incident cases), cerebrovascular disease (CeVD; I6; 79,829/11,664), and coronary heart disease (CHD; I20-I25; 89,657/11,116) for birth cohorts 1935-1950, using German health-claims data from 2004-2015. The data include quarterly information of the inpatient and outpatient treatment. [...]
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2022-07-14
14:34
[DZNE-2022-01321] Preprint
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Social disparities in the first wave of COVID-19 infections in Germany: A county-scale explainable machine learning approach
Little is known about factors correlated with this geographic spread of the first wave of COVID-19 infections in Germany. Given the lack of individual-level socioeconomic information on COVID-19 cases, we resorted to an ecological study design, exploring regional correlates of COVID-19 diagnoses.Data and Method We used data from the Robert-Koch-Institute on COVID-19 diagnoses by sex, age (age groups: 0-4, 5-14, 15-34, 35-59, 60-79, 80+), county (NUTS3 region) differentiating five periods (initial phase: through 15 March; 1st lockdown period: 16 March to 31 March; 2nd lockdown period: from 1 April to 15 April; easing period: 16 April to 30 April; post-lockdown period: 1 May through 23 July). [...]
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2022-07-14
14:30
[DZNE-2022-01320] Preprint
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The second wave of SARS-CoV-2 infections and COVID-19 deaths in Germany – driven by values, social status and migration background? A county-scale explainable machine learning approach
There is a general consensus that SARS-CoV-2 infections and COVID-19 deaths have hit lower social groups the hardest, however, for Germany individual level information on socioeconomic characteristics of infections and deaths does not exist. The aim of this study was to identify the key features explaining SARS-CoV-2 infections and COVID-19 deaths during the upswing of the second wave in Germany. [...]
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2021-11-04
10:34
[DZNE-2021-01299] Preprint
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Lifelong musical activity is associated with multi-domain cognitive and brain benefits in older adults
Regular musical activity as a highly-stimulating lifestyle activity is proposed to be protective against age-related cognitive decline and Alzheimer’s disease (AD). This study investigated associations between lifelong regular musical instrument playing, late-life cognitive abilities and brain morphology in older adults. [...]
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2021-09-11
19:24
[DZNE-2021-01038] Preprint
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Revealing Spatiotemporal Circuit Information of Olfactory Bulb in Large-scale Neural Recordings
Large-scale multi-site biosensors are essential to probe the olfactory bulb (OB) circuitry for understanding the spatiotemporal dynamics of simultaneous discharge patterns. Current ex-vivo electrophysiological techniques are limited to recording a small set of neurons and cannot provide an inadequate resolution, which hinders revealing the fast dynamic underlying the information coding mechanisms in the OB circuit. [...]

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2021-07-28
15:46
OpenAccess [DZNE-2021-00629] Preprint
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Restoring memory by optogenetic synchronization of hippocampal oscillations in an Alzheimer’s disease mouse model
Disrupted neural oscillations are a feature of Alzheimer’s disease (AD). We observed reduced frequency of theta oscillations in the hippocampal local field potential (LFP) in a mouse model of beta-amyloidosis. [...]
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2021-07-21
14:45
[DZNE-2021-00621] Preprint
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The diagonal band of broca regulates olfactory-mediated behaviors by modulating odor-evoked responses within the olfactory bulb
Sensory perception is modulated in a top-down fashion by higher brain regions to regulate the strength of its own input resulting in the adaptation of behavioral responses. In olfactory perception, the horizontal diagonal band of broca (HDB), embedded in the basal forebrain modulates olfactory information processing by recruiting olfactory bulb (OB) interneurons to shape excitatory OB output. [...]
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