Preprint

DZNE-2024-00669

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Circulating microRNAs are related to cognitive domains in the general population

Melas, K. (First author)DZNE* ; Talevi, V.DZNE* ; Etteldorf, R.DZNE* ; Estrada, S.DZNE* ; Krüger, D. M.DZNE* ; Pena, T.DZNE* ; Aziz, N. A.DZNE* ; Fischer, A.DZNE* ; Breteler, M. (Last author)DZNE*

2024

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Please use a persistent id in citations: doi:10.1101/2024.05.07.24306994

Abstract: INTRODUCTION: Circulating microRNAs have been suggested as candidates for detecting and preventing subclinical cognitive dysfunction. However, replication of previous findings and identification of novel microRNAs associated with cognitive domains, including their relation to brain structure and the pathways they regulate, are still lacking.METHODS: We examined circulating microRNAs and microRNA co-expression clusters in relation to cognitive domains, structural MRI measures, and target gene expression in 2869 participants of a population-based cohort.RESULTS: Five previously identified and 10 novel microRNAs were associated with cognitive domains. Importantly, seven of these microRNAs were also associated with cortical thickness and two with hippocampal volume. Functional genomics analysis showed that the identified microRNAs regulated genes in pathways like neurogenesis, axon guidance, and synapse assembly.DISCUSSION: We identified microRNAs associated with cognitive domains, brain regions, and neuronal processes affected by aging and neurodegeneration, making them promising candidate blood-based biomarkers or therapeutic targets of subclinical cognitive dysfunction.

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Contributing Institute(s):

1. Population Health Sciences (AG Breteler)
2. Population & Clinical Neuroepidemiology (AG Aziz)
3. Epigenetics and Systems Medicine in Neurodegenerative Diseases (AG Fischer)

Research Program(s):

1. 354 - Disease Prevention and Healthy Aging (POF4-354) (POF4-354)
2. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Experiment(s):

1. Rhineland Study / Bonn

Appears in the scientific report 2024

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Linked articles:

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Journal Article Melas, K. (First author)DZNE* ; Talevi, V.DZNE* ; Imtiaz, M. A.DZNE* ; Etteldorf, R.DZNE* ; Estrada, S.DZNE* ; Krüger, D. M.DZNE* ; Pena-Centeno, T.DZNE* ; Aziz, N. A.DZNE* ; Fischer, A.DZNE* ; Breteler, M. M. B. (Last author)DZNE*
Blood-derived microRNAs are related to cognitive domains in the general population.
Alzheimer's and dementia 20(10), 7138 - 7159 (2024) [10.1002/alz.14197]2024   Files  Fulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Journal Article/Contribution to a conference proceedings Melas, K. (First author)DZNE* ; Talevi, V.DZNE* ; Krüger, D. M.DZNE* ; Pena, T.DZNE* ; Aziz, N. A.DZNE* ; Fischer, A.DZNE* ; Breteler, M. M. B. (Last author)DZNE*
Circulating microRNAs related to cognitive performance in the general population
2024Alzheimer's Association International Conference, AAIC 2024, PhiladelphiaPhiladelphia, USA, 28 Jul 2024 - 1 Aug 20242024-07-282024-08-01 Alzheimer's and dementia 20(S1), e083648 (2024) [10.1002/alz.083648]2024   Files BibTeX | EndNote: XML, Text | RIS

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