AG Wurst
Genome Engineering
Also known as:AG Wurst; Genom Engineering; Genom-Engineering Einheit
⇧ M DZNE ⇧
Recent Publications
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Sen, P. ; Ortiz, O. ; Brivio, E. ; Menegaz, D. ; Sotillos Elliott, L. ; Du, Y. ; Ries, C. ; Chen, A. ; Wurst, W.DZNE* ; Lopez, J. P. ; Eder, M. ; Deussing, J. M.
A bipolar disorder-associated missense variant alters adenylyl cyclase 2 activity and promotes mania-like behavior.
Molecular psychiatry 30(1), 97 - 110 (2025) [10.1038/s41380-024-02663-w]2025
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Gomez-Diaz, C. ; Greulich, W. ; Wefers, B.DZNE* ; Wang, M. ; Bolsega, S. ; Effern, M. ; Varga, D. P.Extern* ; Han, Z. ; Chen, M. ; Bérouti, M. ; Leonardi, N. ; Schillinger, U. ; Holzmann, B. ; Liesz, A. ; Roers, A. ; Hölzel, M. ; Basic, M. ; Wurst, W.DZNE* ; Hornung, V.
RNase T2 restricts TLR13-mediated autoinflammation in vivo
Journal of experimental medicine 222(3), e20241424 (2025) [10.1084/jem.20241424]2025
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Hang, A. ; Shao, A. ; Shea, M. ; et al
Ocular Phenotyping of Knockout Mice Identifies Genes Associated With Late Adult Retinal Phenotypes.
Investigative ophthalmology & visual science 66(6), 64 (2025) [10.1167/iovs.66.6.64]2025
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de Mello, N. P. ; Berger, M. T. ; Lagerborg, K. A. ; Yan, Y. ; Wettmarshausen, J. ; Keipert, S. ; Weidner, L. ; Tokarz, J. ; Möller, G. ; Ciciliot, S. ; Walia, S. ; Cheng, Y. ; Chudenkova, M. ; Artati, A. ; Weisenhorn, D. V. ; Wurst, W.DZNE* ; Adamski, J. ; Nilsson, R. ; Cossu, G. ; Boon, A. ; Kievit, A. ; Mandemakers, W. ; Bonifati, V. ; Jain, M. ; Jastroch, M. ; Schmitt-Kopplin, P. ; Perocchi, F. ; Dyar, K. A.
Pervasive glycative stress links metabolic imbalance and muscle atrophy in early-onset Parkinson's disease.
Molecular metabolism 97, 102163 (2025) [10.1016/j.molmet.2025.102163]2025
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Asare, Y. ; Yan, G. ; Schlegl, C. ; Prestel, M.Extern* ; van der Vorst, E. P. C. ; Teunissen, A. J. P. ; Aronova, A. ; Tosato, F. ; Naser, N. ; Caputo, J. ; Prevot, G. ; Azzun, A. ; Wefers, B.DZNE* ; Wurst, W.DZNE* ; Schneider, M. ; Forne, I. ; Bidzhekov, K. ; Naumann, R. ; van der Laan, S. W. ; Brandhofer, M. ; Cao, J. ; Roth, S. ; Malik, R. ; Tiedt, S. ; Mulder, W. J. M. ; Imhof, A. ; Liesz, A. ; Weber, C. ; Bernhagen, J. ; Dichgans, M. (Last author)DZNE*
A cis-regulatory element controls expression of histone deacetylase 9 to fine-tune inflammasome-dependent chronic inflammation in atherosclerosis.
Immunity 58(3), 555 - 567.e9 (2025) [10.1016/j.immuni.2025.01.003]2025
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Dunot, J. ; Moreno, S. ; Gandin, C. ; Pousinha, P. A. ; Amici, M. ; Dupuis, J. ; Anisimova, M. ; Winschel, A. ; Uriot, M. ; Petshow, S. J. ; Mensch, M. ; Bethus, I. ; Giudici, C.DZNE* ; Hampel, H. ; Wefers, B.DZNE* ; Wurst, W.DZNE* ; Naumann, R. ; Ashby, M. C. ; Laube, B. ; Zito, K. ; Mellor, J. R. ; Groc, L. ; Willem, M. ; Marie, H.
APP fragment controls both ionotropic and non-ionotropic signaling of NMDA receptors.
Neuron 112(16), 2708 - 2720.e9 (2024) [10.1016/j.neuron.2024.05.027]2024
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Hasenbein, T. P. ; Hoelzl, S. ; Smith, Z. D. ; Gerhardinger, C. ; Gonner, M. O. C. ; Aguilar-Pimentel, A. ; Amarie, O. V. ; Becker, L. ; Calzada-Wack, J. ; Dragano, N. R. V. ; da Silva-Buttkus, P. ; Garrett, L. ; Hölter, S. M. ; Kraiger, M. ; Östereicher, M. A. ; Rathkolb, B. ; Sanz-Moreno, A. ; Spielmann, N. ; Wurst, W.DZNE* ; Gailus-Durner, V. ; Fuchs, H. ; Hrabě de Angelis, M. ; Meissner, A. ; Engelhardt, S. ; Rinn, J. L. ; Andergassen, D.
X-linked deletion of Crossfirre, Firre, and Dxz4 in vivo uncovers diverse phenotypes and combinatorial effects on autosomes.
Nature Communications 15(1), 10631 (2024) [10.1038/s41467-024-54673-5]2024
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Tayaranian Marvian, A. (First author)DZNE* ; Strauß, T.DZNE* ; Tang, Q.DZNE* ; Tuck, B. J. ; Keeling, S. ; Rüdiger, D. ; Mirzazadeh Dizaji, N. ; Mohammad-Beigi, H. ; Nuscher, B. ; Chakraborty, P.Extern* ; Sutherland, D. S. ; McEwan, W. A. ; Köglsperger, T.DZNE* ; Zahler, S. ; Zweckstetter, M.DZNE* ; Lichtenthaler, S. F.DZNE* ; Wurst, W.DZNE* ; Schwarz, S.DZNE* ; Höglinger, G. (Last author)DZNE*
Distinct regulation of Tau Monomer and aggregate uptake and intracellular accumulation in human neurons.
Molecular neurodegeneration 19(1), 100 (2024) [10.1186/s13024-024-00786-w]2024
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Garrett, L. ; Trumbach, D. ; Lee, D. ; et al
Co-expression of prepulse inhibition and Schizophrenia genes in the mouse and human brain
Neuroscience Applied 3, 104075 (2024) [10.1016/j.nsa.2024.104075]2024
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Kaji, S.DZNE* ; Berghoff, S. A.DZNE* ; Spieth, L.DZNE* ; Schlaphoff, L.DZNE* ; Sasmita, A. O. ; Vitale, S.DZNE* ; Büschgens, L. ; Kedia, S.DZNE* ; Zirngibl, M.DZNE* ; Nazarenko, T.DZNE* ; Damkou, A.DZNE* ; Hosang, L. ; Depp, C. ; Kamp, F.DZNE* ; Scholz, P. ; Ewers, D. ; Giera, M. ; Ischebeck, T. ; Wurst, W.DZNE* ; Wefers, B.DZNE* ; Schifferer, M.DZNE* ; Willem, M. ; Nave, K.-A. ; Haass, C.DZNE* ; Arzberger, T.Extern* ; Jäkel, S. ; Wirths, O. ; Saher, G. ; Simons, M. (Last author)DZNE*
Apolipoprotein E aggregation in microglia initiates Alzheimer's disease pathology by seeding β-amyloidosis.
Immunity 57(11), 2651 - 2668.e12 (2024) [10.1016/j.immuni.2024.09.014]2024
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All known publications ...
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