AG Wurst
Genome Engineering
Also known as:AG Wurst; Genom Engineering; Genom-Engineering Einheit
⇧ M DZNE ⇧
Recent Publications
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Feiten, A. F. (First author)DZNE* ; Dahm, K. (First author)DZNE* ; Schlepckow, K. (First author)DZNE* ; van Lengerich, B. ; Suh, J. H. ; Reifschneider, A. ; Wefers, B.DZNE* ; Bartos, L. M. ; Wind, K.Extern* ; de Weerd, L.DZNE* ; Ulas, T.DZNE* ; De-Domenico, E.DZNE* ; Grundschöttel, P.DZNE* ; Paulusch, S.DZNE* ; Tast, B. ; Honda, T. ; Müller, S. A.DZNE* ; Becker, M.DZNE* ; Khalin, I. ; Ricci, A. ; Liesz, A. ; Brunner, B.DZNE* ; Krenner, C.Extern* ; Buschmann, K.Extern* ; Nuscher, B. ; Spieth, L.DZNE* ; Junker, N.DZNE* ; Berghoff, S. A.DZNE* ; Davis, S. S. ; Neher, J. J.DZNE* ; Wurst, W.DZNE* ; Plesnila, N. ; Lewcock, J. W. ; Simons, M.DZNE* ; Lichtenthaler, S. F.DZNE* ; Di Paolo, G. ; Brendel, M.DZNE* ; Capell, A.DZNE* ; Monroe, K. M. ; Schultze, J. L.DZNE* ; Haass, C. (Last author)DZNE*
TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism.
Nature Communications 17(1), 2002 (2026) [10.1038/s41467-026-68706-8]2026
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Heger, L.Extern* ; Gubinelli, F.Extern* ; Huber, A. J. ; Cardona-Alberich, A. ; Rovere, M.Extern* ; Matti, U. ; Müller, S. A.DZNE* ; Nagaraja, S.Extern* ; Jaschkowitz, L. ; Schifferer, M.DZNE* ; Wurst, W.DZNE* ; Lichtenthaler, S. F.DZNE* ; Behrends, C. ; Sambandan, S. ; Burbulla, L. F. (Last author)DZNE*
VMAT2 dysfunction impairs vesicular dopamine uptake, driving its oxidation and α-synuclein pathology in DJ-1-linked Parkinson's neurons.
Science advances 12(7), eadz5645 (2026) [10.1126/sciadv.adz5645]2026
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Nguyen, T. N. ; Ribes, S. ; Andrique, C. ; Requin, M. ; Bouchet, J. ; Obtel, N. ; Slimani, L. ; Brouilly, N. ; Torrens, C. ; Schmitt, A. ; Guilbert, T. ; Morawietz, M. ; Kiesow, A. ; Brunelle, A. ; Percot, A. ; Hadj-Rabia, S. ; Gaucher, C. ; Le Bivic, A. ; Houillier, P. ; Bardet, C. ; Muller, D. ; Ramirez Rozzi, F. ; Coradin, T. ; Breiderhoff, T.DZNE* ; Chaussain, C.
The Absence of Claudin-10 in the Enamel Organ Alters Its Integrity.
Journal of dental research 105(3), 385 - 395 (2026) [10.1177/00220345251349109]2026
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Heininger, H. ; Feng, X.DZNE* ; Altunkaya, A. ; Zheng, F. ; Stockinger, F. ; Wefers, B.DZNE* ; Müller, S. A.DZNE* ; Giesbertz, P.DZNE* ; Tschirner, S.DZNE* ; Shqau, D.DZNE* ; Adelsberger, H. ; Ponomarenko, A. ; Fenzl, T. ; Alzheimer, C. ; Lichtenthaler, S. F. (Last author)DZNE* ; Huth, T.
BACE1 regulates sleep–wake cycle through both enzymatic and non–enzymatic actions
EMBO reports 27, 50 - 68 (2026) [10.1038/s44319-025-00604-4]2026
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Jakob, M. O. ; Sterczyk, N. ; Boulekou, S. ; Forster, P. M. ; Barleben, L. ; Alzain, N. ; Jarick, K. J. ; Pirzgalska, R. M. ; Raposo, B. ; Hansson, K. ; Nyström, E. E. L. ; Gondrand, A. ; González-Acera, M. ; Leclère, P. S. ; Lapson, M. S. ; Poggenseier, S. ; Deshpande, D. ; Velleman, L. ; Breiderhoff, T.DZNE* ; Brunkhorst, M. F. ; Schüle, A. M. ; Guerra, G. M. ; Durek, P. ; Mashreghi, M.-F. ; Kühl, A. A. ; Chu, C. ; Schneider, C. ; Weidinger, C. ; Siegmund, B. ; Nordmann, T. M. ; Voehringer, D. ; Patankar, J. V. ; Becker, C. ; Birchenough, G. M. H. ; Veiga-Fernandes, H. ; Ronchi, F. ; Kolesnichenko, M. ; Diefenbach, A. ; Klose, C. S. N.
Enteric nervous system-derived VIP restrains differentiation of LGR5+ stem cells toward the secretory lineage impeding type 2 immune programs.
Nature immunology 26(12), 2227 - 2243 (2025) [10.1038/s41590-025-02325-1]2025
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von Mücke-Heim, I.-A. ; Oldekamp, J. ; Metzger, M. W. ; Kläffgen, S. ; Tang, H. ; Walser, S. M. ; Dedic, N. ; Rammes, G. ; Holsboer, F. ; Wurst, W.DZNE* ; Deussing, J. M.
Establishment and behavioural characterization of a novel constitutive P2X7 receptor knockout mouse line.
Purinergic signalling 21(5), 1077 - 1092 (2025) [10.1007/s11302-025-10074-x]2025
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Bhattacharya, D.Extern* ; da Silva-Buttkus, P. ; Nalbach, K.DZNE* ; Cheng, L.Extern* ; Garrett, L. ; Irmler, M. ; Kislinger, G.DZNE* ; Werner, G.Extern* ; Rodde, R. ; Lengger, C. ; Beckers, J. ; Zimprich, A. ; Hölter, S. M. ; Gailus-Durner, V. ; Fuchs, H. ; Hrabe de Angelis, M. ; Wefers, B.DZNE* ; Wurst, W.DZNE* ; Brill, M. S. ; Schifferer, M.DZNE* ; Lichtenthaler, S. F.DZNE* ; Behrends, C.
Neuropathy-associated Tecpr2 mutation knock-in mice reveal endolysosomal loss of function phenotypes in neurons and microglia.
Cell death & disease 16(1), 775 (2025) [10.1038/s41419-025-08168-w]2025
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Hang, A. ; Shao, A. ; Shea, M. ; et al
Ocular Phenotyping of Knockout Mice Identifies Genes Associated With Late Adult Retinal Phenotypes.
Investigative ophthalmology & visual science 66(6), 64 (2025) [10.1167/iovs.66.6.64]2025
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de Mello, N. P. ; Berger, M. T. ; Lagerborg, K. A. ; Yan, Y. ; Wettmarshausen, J. ; Keipert, S. ; Weidner, L. ; Tokarz, J. ; Möller, G. ; Ciciliot, S. ; Walia, S. ; Cheng, Y. ; Chudenkova, M. ; Artati, A. ; Weisenhorn, D. V. ; Wurst, W.DZNE* ; Adamski, J. ; Nilsson, R. ; Cossu, G. ; Boon, A. ; Kievit, A. ; Mandemakers, W. ; Bonifati, V. ; Jain, M. ; Jastroch, M. ; Schmitt-Kopplin, P. ; Perocchi, F. ; Dyar, K. A.
Pervasive glycative stress links metabolic imbalance and muscle atrophy in early-onset Parkinson's disease.
Molecular metabolism 97, 102163 (2025) [10.1016/j.molmet.2025.102163]2025
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Asare, Y. ; Yan, G. ; Schlegl, C. ; Prestel, M.Extern* ; van der Vorst, E. P. C. ; Teunissen, A. J. P. ; Aronova, A. ; Tosato, F. ; Naser, N. ; Caputo, J. ; Prevot, G. ; Azzun, A. ; Wefers, B.DZNE* ; Wurst, W.DZNE* ; Schneider, M. ; Forne, I. ; Bidzhekov, K. ; Naumann, R. ; van der Laan, S. W. ; Brandhofer, M. ; Cao, J. ; Roth, S. ; Malik, R. ; Tiedt, S. ; Mulder, W. J. M. ; Imhof, A. ; Liesz, A. ; Weber, C. ; Bernhagen, J. ; Dichgans, M. (Last author)DZNE*
A cis-regulatory element controls expression of histone deacetylase 9 to fine-tune inflammasome-dependent chronic inflammation in atherosclerosis.
Immunity 58(3), 555 - 567.e9 (2025) [10.1016/j.immuni.2025.01.003]2025
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All known publications ...
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