Journal Article (Review Article)

DZNE-2020-02384

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Paraquat and Parkinson's disease.

Berry, C. ; La Vecchia, C. ; Nicotera, P. (Last author)DZNE*

2010
Macmillan London

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Please use a persistent id in citations: doi:10.1038/cdd.2009.217

Abstract: As evidence emerges that complex gene alterations are involved in the onset of Parkinson's disease (PD), the role of environmental chemicals in the pathogenesis of this disease becomes intensely debated. Although it is undisputed that acute exposure to certain chemicals such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is sufficient to cause human parkinsonism, the evidence that the risk for PD increases because of environmental exposure is generally weaker. Several studies have suggested that pesticide exposure and life in rural areas are significant risks factors for PD. Among other pesticides, paraquat (PQ) has been linked to PD by epidemiological studies and experimental work in rodents, in which it causes lesions in the substantia nigra, pars compacta. However, the evidence that human exposure to the chemical results in an increased risk for PD is rather limited and based on insufficient epidemiological data. This review critically analyses the evidence that implicates PQ in parkinsonism and discusses the limitations of chemical modelling of PD.

Keyword(s): Animals (MeSH) ; Apoptosis (MeSH) ; Disease Models, Animal (MeSH) ; Herbicides: toxicity (MeSH) ; Humans (MeSH) ; Mice (MeSH) ; Nerve Degeneration: etiology (MeSH) ; Paraquat: toxicity (MeSH) ; Parkinson Disease: epidemiology (MeSH) ; Parkinson Disease: etiology (MeSH) ; Risk Factors (MeSH) ; Herbicides ; Paraquat

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Contributing Institute(s):

1. Synaptic Connectivity and Neurodegeneration (AG Nicotera)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)

Appears in the scientific report 2010

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; PubMed Central ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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