Journal Article (Review Article)

DZNE-2020-02394

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Biomarkers for Alzheimer's disease: academic, industry and regulatory perspectives.

Hampel, H. (Corresponding author) ; Frank, R. ; Broich, K. ; Teipel, S. J.DZNE* ; Katz, R. G. ; Hardy, J. ; Herholz, K. ; Bokde, A. L. W. ; Jessen, F.DZNE* ; Hoessler, Y. C. ; Sanhai, W. R. ; Zetterberg, H. ; Woodcock, J. ; Blennow, K.

2010
Nature Publ. Group London

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Please use a persistent id in citations: doi:10.1038/nrd3115

Abstract: Advances in therapeutic strategies for Alzheimer's disease that lead to even small delays in onset and progression of the condition would significantly reduce the global burden of the disease. To effectively test compounds for Alzheimer's disease and bring therapy to individuals as early as possible there is an urgent need for collaboration between academic institutions, industry and regulatory organizations for the establishment of standards and networks for the identification and qualification of biological marker candidates. Biomarkers are needed to monitor drug safety, to identify individuals who are most likely to respond to specific treatments, to stratify presymptomatic patients and to quantify the benefits of treatments. Biomarkers that achieve these characteristics should enable objective business decisions in portfolio management and facilitate regulatory approval of new therapies.

Keyword(s): Alzheimer Disease: diagnosis (MeSH) ; Alzheimer Disease: genetics (MeSH) ; Animals (MeSH) ; Biomarkers (MeSH) ; Clinical Trials as Topic (MeSH) ; Drug Discovery: legislation & jurisprudence (MeSH) ; Drug Discovery: trends (MeSH) ; Drug Industry: trends (MeSH) ; Endpoint Determination (MeSH) ; Humans (MeSH) ; Magnetic Resonance Imaging (MeSH) ; Molecular Biology (MeSH) ; Positron-Emission Tomography (MeSH) ; Risk Assessment (MeSH) ; Biomarkers

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Contributing Institute(s):

1. Clinical Dementia Research Rostock /Greifswald (Clinical Dementia Research Rostock /Greifswald ; AG Teipel)
2. Patient studies cologne (AG Jessen)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)

Appears in the scientific report 2010

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Database coverage:
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 50 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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