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000136075 0247_ $$2pmc$$apmc:PMC6632833
000136075 0247_ $$2ISSN$$a0270-6474
000136075 0247_ $$2ISSN$$a1529-2401
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000136075 037__ $$aDZNE-2020-02397
000136075 041__ $$aEnglish
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000136075 1001_ $$0P:(DE-HGF)0$$aBaier, Bernhard$$b0$$eCorresponding author
000136075 245__ $$aKeeping memory clear and stable--the contribution of human basal ganglia and prefrontal cortex to working memory.
000136075 260__ $$aWashington, DC$$bSoc.57413$$c2010
000136075 264_1 $$2Crossref$$3online$$bSociety for Neuroscience$$c2010-07-21
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000136075 520__ $$aSuccessful remembering involves both hindering irrelevant information from entering working memory (WM) and actively maintaining relevant information online. Using a voxelwise lesion-behavior brain mapping approach in stroke patients, we observed that lesions of the left basal ganglia render WM susceptible to irrelevant information. Lesions of the right prefrontal cortex on the other hand make it difficult to keep more than a few items in WM. These findings support basal ganglia-prefrontal cortex models of WM whereby the basal ganglia play a gatekeeper role and allow only relevant information to enter prefrontal cortex where this information then is actively maintained in WM.
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000136075 650_2 $$2MeSH$$aAdult
000136075 650_2 $$2MeSH$$aAged
000136075 650_2 $$2MeSH$$aAged, 80 and over
000136075 650_2 $$2MeSH$$aBasal Ganglia: physiology
000136075 650_2 $$2MeSH$$aBrain Mapping
000136075 650_2 $$2MeSH$$aFemale
000136075 650_2 $$2MeSH$$aHumans
000136075 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000136075 650_2 $$2MeSH$$aMale
000136075 650_2 $$2MeSH$$aMemory Disorders: diagnosis
000136075 650_2 $$2MeSH$$aMemory Disorders: etiology
000136075 650_2 $$2MeSH$$aMemory Disorders: physiopathology
000136075 650_2 $$2MeSH$$aMemory, Short-Term: physiology
000136075 650_2 $$2MeSH$$aMiddle Aged
000136075 650_2 $$2MeSH$$aPrefrontal Cortex: physiology
000136075 650_2 $$2MeSH$$aPutamen: physiology
000136075 650_2 $$2MeSH$$aPutamen: physiopathology
000136075 650_2 $$2MeSH$$aStroke: complications
000136075 650_2 $$2MeSH$$aStroke: pathology
000136075 650_2 $$2MeSH$$aStroke: physiopathology
000136075 7001_ $$0P:(DE-HGF)0$$aKarnath, Hans-Otto$$b1
000136075 7001_ $$0P:(DE-HGF)0$$aDieterich, Marianne$$b2
000136075 7001_ $$0P:(DE-HGF)0$$aBirklein, Frank$$b3
000136075 7001_ $$0P:(DE-HGF)0$$aHeinze, Carolin$$b4
000136075 7001_ $$0P:(DE-2719)2191623$$aMüller, Notger G$$b5$$eLast author
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