Journal Article

DZNE-2020-02397

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Keeping memory clear and stable--the contribution of human basal ganglia and prefrontal cortex to working memory.

Baier, B. (Corresponding author) ; Karnath, H.-O. ; Dieterich, M. ; Birklein, F. ; Heinze, C. ; Müller, N. G. (Last author)DZNE*

2010
Soc.57413 Washington, DC

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Please use a persistent id in citations: doi:10.1523/JNEUROSCI.1513-10.2010

Abstract: Successful remembering involves both hindering irrelevant information from entering working memory (WM) and actively maintaining relevant information online. Using a voxelwise lesion-behavior brain mapping approach in stroke patients, we observed that lesions of the left basal ganglia render WM susceptible to irrelevant information. Lesions of the right prefrontal cortex on the other hand make it difficult to keep more than a few items in WM. These findings support basal ganglia-prefrontal cortex models of WM whereby the basal ganglia play a gatekeeper role and allow only relevant information to enter prefrontal cortex where this information then is actively maintained in WM.

Keyword(s): Adult (MeSH) ; Aged (MeSH) ; Aged, 80 and over (MeSH) ; Basal Ganglia: physiology (MeSH) ; Brain Mapping (MeSH) ; Female (MeSH) ; Humans (MeSH) ; Magnetic Resonance Imaging (MeSH) ; Male (MeSH) ; Memory Disorders: diagnosis (MeSH) ; Memory Disorders: etiology (MeSH) ; Memory Disorders: physiopathology (MeSH) ; Memory, Short-Term: physiology (MeSH) ; Middle Aged (MeSH) ; Prefrontal Cortex: physiology (MeSH) ; Putamen: physiology (MeSH) ; Putamen: physiopathology (MeSH) ; Stroke: complications (MeSH) ; Stroke: pathology (MeSH) ; Stroke: physiopathology (MeSH)

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Contributing Institute(s):

1. Neuroprotection (AG Müller)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)

Appears in the scientific report 2010

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; PubMed Central ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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