TY  - JOUR
AU  - Baier, Bernhard
AU  - Karnath, Hans-Otto
AU  - Dieterich, Marianne
AU  - Birklein, Frank
AU  - Heinze, Carolin
AU  - Müller, Notger G
TI  - Keeping memory clear and stable-the contribution of human basal ganglia and prefrontal cortex to working memory.
JO  - The journal of neuroscience
VL  - 30
IS  - 29
SN  - 0270-6474
CY  - Washington, DC
PB  - Soc.57413
M1  - DZNE-2020-02397
SP  - 9788-9792
PY  - 2010
AB  - Successful remembering involves both hindering irrelevant information from entering working memory (WM) and actively maintaining relevant information online. Using a voxelwise lesion-behavior brain mapping approach in stroke patients, we observed that lesions of the left basal ganglia render WM susceptible to irrelevant information. Lesions of the right prefrontal cortex on the other hand make it difficult to keep more than a few items in WM. These findings support basal ganglia-prefrontal cortex models of WM whereby the basal ganglia play a gatekeeper role and allow only relevant information to enter prefrontal cortex where this information then is actively maintained in WM.
KW  - Adult
KW  - Aged
KW  - Aged, 80 and over
KW  - Basal Ganglia: physiology
KW  - Brain Mapping
KW  - Female
KW  - Humans
KW  - Magnetic Resonance Imaging
KW  - Male
KW  - Memory Disorders: diagnosis
KW  - Memory Disorders: etiology
KW  - Memory Disorders: physiopathology
KW  - Memory, Short-Term: physiology
KW  - Middle Aged
KW  - Prefrontal Cortex: physiology
KW  - Putamen: physiology
KW  - Putamen: physiopathology
KW  - Stroke: complications
KW  - Stroke: pathology
KW  - Stroke: physiopathology
LB  - PUB:(DE-HGF)16
C6  - pmid:20660261
C2  - pmc:PMC6632833
DO  - DOI:10.1523/JNEUROSCI.1513-10.2010
UR  - https://pub.dzne.de/record/136075
ER  -