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000136185 037__ $$aDZNE-2020-02507
000136185 041__ $$aEnglish
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000136185 1001_ $$0P:(DE-2719)2380511$$aSpringer, Wolfdieter$$b0$$eFirst author$$udzne
000136185 245__ $$aRegulation of PINK1-Parkin-mediated mitophagy.
000136185 260__ $$aAbingdon, Oxon$$bTaylor & Francis$$c2011
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000136185 520__ $$aParkinson disease (PD) is a devastating disorder of the nervous system for which no cure exists. Although the exact mechanisms involved in the pathogenesis of PD are unclear, very recently, a novel cellular process has been identified that promises great future potential. Two PD-associated genes have been found to converge on the emerging mitophagy pathway that links the two major cellular dysfunctions implicated in the pathogenesis of PD. Thereby, PINK1 and Parkin physically associate and functionally cooperate to identify and label damaged mitochondria for selective degradation via autophagy. PD-associated mutations in both genes disrupt mitophagy although through different mechanisms, revealing a sequential multistep process. Further key players that tie into this process have been identified and provide the framework for future research aiming at a complete dissection of this neuroprotective pathway. This may not only yield novel targets for therapeutic intervention in PD, but possibly for other neurodegenerative disorders as well.
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000136185 650_7 $$0EC 2.3.2.27$$2NLM Chemicals$$aUbiquitin-Protein Ligases
000136185 650_7 $$0EC 2.3.2.27$$2NLM Chemicals$$aparkin protein
000136185 650_7 $$0EC 2.7.-$$2NLM Chemicals$$aProtein Kinases
000136185 650_7 $$0EC 2.7.11.1$$2NLM Chemicals$$aPTEN-induced putative kinase
000136185 650_2 $$2MeSH$$aAnimals
000136185 650_2 $$2MeSH$$aAutophagy
000136185 650_2 $$2MeSH$$aHumans
000136185 650_2 $$2MeSH$$aMitochondria: enzymology
000136185 650_2 $$2MeSH$$aParkinson Disease: enzymology
000136185 650_2 $$2MeSH$$aParkinson Disease: pathology
000136185 650_2 $$2MeSH$$aProtein Kinases: metabolism
000136185 650_2 $$2MeSH$$aProteolysis
000136185 650_2 $$2MeSH$$aUbiquitin-Protein Ligases: metabolism
000136185 7001_ $$0P:(DE-2719)2810803$$aKahle, Philipp J$$b1$$eLast author$$udzne
000136185 77318 $$2Crossref$$3journal-article$$a10.4161/auto.7.3.14348$$b : Informa UK Limited, 2011-03-01$$n3$$p266-278$$tAutophagy$$v7$$x1554-8627$$y2011
000136185 773__ $$0PERI:(DE-600)2262043-6$$a10.4161/auto.7.3.14348$$gVol. 7, no. 3, p. 266 - 278$$n3$$p266-278$$q7:3<266 - 278$$tAutophagy$$v7$$x1554-8627$$y2011
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