Journal Article (Review Article)

DZNE-2020-02507

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Regulation of PINK1-Parkin-mediated mitophagy.

Springer, W. (First author)DZNE* ; Kahle, P. J. (Last author)DZNE*

2011
Taylor & Francis Abingdon, Oxon

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Please use a persistent id in citations: doi:10.4161/auto.7.3.14348

Abstract: Parkinson disease (PD) is a devastating disorder of the nervous system for which no cure exists. Although the exact mechanisms involved in the pathogenesis of PD are unclear, very recently, a novel cellular process has been identified that promises great future potential. Two PD-associated genes have been found to converge on the emerging mitophagy pathway that links the two major cellular dysfunctions implicated in the pathogenesis of PD. Thereby, PINK1 and Parkin physically associate and functionally cooperate to identify and label damaged mitochondria for selective degradation via autophagy. PD-associated mutations in both genes disrupt mitophagy although through different mechanisms, revealing a sequential multistep process. Further key players that tie into this process have been identified and provide the framework for future research aiming at a complete dissection of this neuroprotective pathway. This may not only yield novel targets for therapeutic intervention in PD, but possibly for other neurodegenerative disorders as well.

Keyword(s): Animals (MeSH) ; Autophagy (MeSH) ; Humans (MeSH) ; Mitochondria: enzymology (MeSH) ; Parkinson Disease: enzymology (MeSH) ; Parkinson Disease: pathology (MeSH) ; Protein Kinases: metabolism (MeSH) ; Proteolysis (MeSH) ; Ubiquitin-Protein Ligases: metabolism (MeSH) ; Ubiquitin-Protein Ligases ; parkin protein ; Protein Kinases ; PTEN-induced putative kinase

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Contributing Institute(s):

1. Functional Neurogenetics (AG Kahle)

Research Program(s):

1. 345 - Population Studies and Genetics (POF3-345) (POF3-345)

Appears in the scientific report 2011

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; IF >= 10 ; JCR ; NCBI Molecular Biology Database ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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