TY  - JOUR
AU  - Springer, Wolfdieter
AU  - Kahle, Philipp J
TI  - Regulation of PINK1-Parkin-mediated mitophagy.
JO  - Autophagy
VL  - 7
IS  - 3
SN  - 1554-8627
CY  - Abingdon, Oxon
PB  - Taylor & Francis
M1  - DZNE-2020-02507
SP  - 266-278
PY  - 2011
AB  - Parkinson disease (PD) is a devastating disorder of the nervous system for which no cure exists. Although the exact mechanisms involved in the pathogenesis of PD are unclear, very recently, a novel cellular process has been identified that promises great future potential. Two PD-associated genes have been found to converge on the emerging mitophagy pathway that links the two major cellular dysfunctions implicated in the pathogenesis of PD. Thereby, PINK1 and Parkin physically associate and functionally cooperate to identify and label damaged mitochondria for selective degradation via autophagy. PD-associated mutations in both genes disrupt mitophagy although through different mechanisms, revealing a sequential multistep process. Further key players that tie into this process have been identified and provide the framework for future research aiming at a complete dissection of this neuroprotective pathway. This may not only yield novel targets for therapeutic intervention in PD, but possibly for other neurodegenerative disorders as well.
KW  - Animals
KW  - Autophagy
KW  - Humans
KW  - Mitochondria: enzymology
KW  - Parkinson Disease: enzymology
KW  - Parkinson Disease: pathology
KW  - Protein Kinases: metabolism
KW  - Proteolysis
KW  - Ubiquitin-Protein Ligases: metabolism
KW  - Ubiquitin-Protein Ligases (NLM Chemicals)
KW  - parkin protein (NLM Chemicals)
KW  - Protein Kinases (NLM Chemicals)
KW  - PTEN-induced putative kinase (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:21187721
DO  - DOI:10.4161/auto.7.3.14348
UR  - https://pub.dzne.de/record/136185
ER  -