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@ARTICLE{Springer:136185,
      author       = {Springer, Wolfdieter and Kahle, Philipp J},
      title        = {{R}egulation of {PINK}1-{P}arkin-mediated mitophagy.},
      journal      = {Autophagy},
      volume       = {7},
      number       = {3},
      issn         = {1554-8627},
      address      = {Abingdon, Oxon},
      publisher    = {Taylor $\&$ Francis},
      reportid     = {DZNE-2020-02507},
      pages        = {266-278},
      year         = {2011},
      abstract     = {Parkinson disease (PD) is a devastating disorder of the
                      nervous system for which no cure exists. Although the exact
                      mechanisms involved in the pathogenesis of PD are unclear,
                      very recently, a novel cellular process has been identified
                      that promises great future potential. Two PD-associated
                      genes have been found to converge on the emerging mitophagy
                      pathway that links the two major cellular dysfunctions
                      implicated in the pathogenesis of PD. Thereby, PINK1 and
                      Parkin physically associate and functionally cooperate to
                      identify and label damaged mitochondria for selective
                      degradation via autophagy. PD-associated mutations in both
                      genes disrupt mitophagy although through different
                      mechanisms, revealing a sequential multistep process.
                      Further key players that tie into this process have been
                      identified and provide the framework for future research
                      aiming at a complete dissection of this neuroprotective
                      pathway. This may not only yield novel targets for
                      therapeutic intervention in PD, but possibly for other
                      neurodegenerative disorders as well.},
      subtyp        = {Review Article},
      keywords     = {Animals / Autophagy / Humans / Mitochondria: enzymology /
                      Parkinson Disease: enzymology / Parkinson Disease: pathology
                      / Protein Kinases: metabolism / Proteolysis /
                      Ubiquitin-Protein Ligases: metabolism / Ubiquitin-Protein
                      Ligases (NLM Chemicals) / parkin protein (NLM Chemicals) /
                      Protein Kinases (NLM Chemicals) / PTEN-induced putative
                      kinase (NLM Chemicals)},
      cin          = {AG Kahle},
      ddc          = {570},
      cid          = {I:(DE-2719)1210000-4},
      pnm          = {345 - Population Studies and Genetics (POF3-345)},
      pid          = {G:(DE-HGF)POF3-345},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:21187721},
      doi          = {10.4161/auto.7.3.14348},
      url          = {https://pub.dzne.de/record/136185},
}