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001     136185
005     20250411151432.0
024 7 _ |a 10.4161/auto.7.3.14348
|2 doi
024 7 _ |a pmid:21187721
|2 pmid
024 7 _ |a 1554-8627
|2 ISSN
024 7 _ |a 1554-8635
|2 ISSN
024 7 _ |a altmetric:3466127
|2 altmetric
037 _ _ |a DZNE-2020-02507
041 _ _ |a English
082 _ _ |a 570
100 1 _ |a Springer, Wolfdieter
|0 P:(DE-2719)2380511
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|e First author
|u dzne
245 _ _ |a Regulation of PINK1-Parkin-mediated mitophagy.
260 _ _ |a Abingdon, Oxon
|c 2011
|b Taylor & Francis
264 _ 1 |3 online
|2 Crossref
|b Informa UK Limited
|c 2014-10-27
264 _ 1 |3 print
|2 Crossref
|b Informa UK Limited
|c 2011-03-01
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
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336 7 _ |a Journal Article
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|s 1744377232_23681
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|x Review Article
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a Parkinson disease (PD) is a devastating disorder of the nervous system for which no cure exists. Although the exact mechanisms involved in the pathogenesis of PD are unclear, very recently, a novel cellular process has been identified that promises great future potential. Two PD-associated genes have been found to converge on the emerging mitophagy pathway that links the two major cellular dysfunctions implicated in the pathogenesis of PD. Thereby, PINK1 and Parkin physically associate and functionally cooperate to identify and label damaged mitochondria for selective degradation via autophagy. PD-associated mutations in both genes disrupt mitophagy although through different mechanisms, revealing a sequential multistep process. Further key players that tie into this process have been identified and provide the framework for future research aiming at a complete dissection of this neuroprotective pathway. This may not only yield novel targets for therapeutic intervention in PD, but possibly for other neurodegenerative disorders as well.
536 _ _ |a 345 - Population Studies and Genetics (POF3-345)
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|c POF3-345
|f POF III
|x 0
588 _ _ |a Dataset connected to CrossRef, PubMed,
650 _ 7 |a Ubiquitin-Protein Ligases
|0 EC 2.3.2.27
|2 NLM Chemicals
650 _ 7 |a parkin protein
|0 EC 2.3.2.27
|2 NLM Chemicals
650 _ 7 |a Protein Kinases
|0 EC 2.7.-
|2 NLM Chemicals
650 _ 7 |a PTEN-induced putative kinase
|0 EC 2.7.11.1
|2 NLM Chemicals
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Autophagy
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Mitochondria: enzymology
|2 MeSH
650 _ 2 |a Parkinson Disease: enzymology
|2 MeSH
650 _ 2 |a Parkinson Disease: pathology
|2 MeSH
650 _ 2 |a Protein Kinases: metabolism
|2 MeSH
650 _ 2 |a Proteolysis
|2 MeSH
650 _ 2 |a Ubiquitin-Protein Ligases: metabolism
|2 MeSH
700 1 _ |a Kahle, Philipp J
|0 P:(DE-2719)2810803
|b 1
|e Last author
|u dzne
773 1 8 |a 10.4161/auto.7.3.14348
|b : Informa UK Limited, 2011-03-01
|n 3
|p 266-278
|3 journal-article
|2 Crossref
|t Autophagy
|v 7
|y 2011
|x 1554-8627
773 _ _ |a 10.4161/auto.7.3.14348
|g Vol. 7, no. 3, p. 266 - 278
|0 PERI:(DE-600)2262043-6
|n 3
|q 7:3<266 - 278
|p 266-278
|t Autophagy
|v 7
|y 2011
|x 1554-8627
856 4 _ |u https://pub.dzne.de/record/136185/files/DZNE-2020-02507_Restricted.pdf
856 4 _ |u https://pub.dzne.de/record/136185/files/DZNE-2020-02507_Restricted.pdf?subformat=pdfa
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909 C O |p VDB
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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913 1 _ |a DE-HGF
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914 1 _ |y 2011
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980 _ _ |a UNRESTRICTED

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