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000136241 0247_ $$2ISSN$$a0005-7851
000136241 0247_ $$2doi$$a10.1007/s10519-010-9398-1
000136241 0247_ $$2pmid$$apmid:20882401
000136241 0247_ $$2pmc$$apmc:PMC3102774
000136241 0247_ $$2ISSN$$a0001-8244
000136241 0247_ $$2ISSN$$a1573-3297
000136241 037__ $$aDZNE-2020-02563
000136241 041__ $$aEnglish
000136241 082__ $$a570
000136241 1001_ $$0P:(DE-2719)2289209$$aEhninger, Dan$$b0$$eFirst author$$udzne
000136241 245__ $$aIncreased levels of anxiety-related behaviors in a Tsc2 dominant negative transgenic mouse model of tuberous sclerosis.
000136241 260__ $$aDordrecht [u.a.]$$bSpringer Science + Business Media B.V$$c2011
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000136241 520__ $$aTuberous sclerosis (TSC) is a single-gene disorder caused by heterozygous mutations in the TSC1 or TSC2 gene. TSC is often associated with neurological (e.g., epilepsy), cognitive (intellectual disabilities, specific neuropsychological impairments) and behavioral pathologies (e.g., autism, attention deficit hyperactivity disorder). In addition, there is a high prevalence of psychiatric problems in TSC populations, including anxiety and mood disorders. To date, little is known about the pathogenetic bases of these associated psychiatric symptoms; for instance, it is unclear whether they are rooted in TSC-associated neurobiological alterations or whether they are secondary psychological phenomena (e.g., because individuals have to cope with the burden of the disease). Here, we report elevated levels of anxiety-related behaviors and mild deficits in two hippocampal-dependent learning tasks in a Tsc2 dominant negative transgenic mouse model of TSC. These findings establish a mouse model for TSC-related anxiety phenotypes and suggest that anxiety disorders in TSC have a biological foundation.
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000136241 650_7 $$2NLM Chemicals$$aTSC2 protein, human
000136241 650_7 $$2NLM Chemicals$$aTsc2 protein, mouse
000136241 650_7 $$2NLM Chemicals$$aTuberous Sclerosis Complex 2 Protein
000136241 650_7 $$2NLM Chemicals$$aTumor Suppressor Proteins
000136241 650_2 $$2MeSH$$aAnimals
000136241 650_2 $$2MeSH$$aAnxiety: genetics
000136241 650_2 $$2MeSH$$aDisease Models, Animal
000136241 650_2 $$2MeSH$$aFemale
000136241 650_2 $$2MeSH$$aGenes, Dominant: genetics
000136241 650_2 $$2MeSH$$aGenetic Carrier Screening
000136241 650_2 $$2MeSH$$aHippocampus: physiopathology
000136241 650_2 $$2MeSH$$aHumans
000136241 650_2 $$2MeSH$$aLearning Disabilities: genetics
000136241 650_2 $$2MeSH$$aLearning Disabilities: physiopathology
000136241 650_2 $$2MeSH$$aMale
000136241 650_2 $$2MeSH$$aMemory Disorders: genetics
000136241 650_2 $$2MeSH$$aMemory Disorders: physiopathology
000136241 650_2 $$2MeSH$$aMice
000136241 650_2 $$2MeSH$$aMice, Inbred C57BL
000136241 650_2 $$2MeSH$$aMice, Transgenic
000136241 650_2 $$2MeSH$$aPhenotype
000136241 650_2 $$2MeSH$$aTuberous Sclerosis: genetics
000136241 650_2 $$2MeSH$$aTuberous Sclerosis: physiopathology
000136241 650_2 $$2MeSH$$aTuberous Sclerosis Complex 2 Protein
000136241 650_2 $$2MeSH$$aTumor Suppressor Proteins: genetics
000136241 7001_ $$0P:(DE-HGF)0$$aSilva, Alcino J$$b1
000136241 77318 $$2Crossref$$3journal-article$$a10.1007/s10519-010-9398-1$$b : Springer Science and Business Media LLC, 2010-09-30$$n3$$p357-363$$tBehavior Genetics$$v41$$x0001-8244$$y2010
000136241 773__ $$0PERI:(DE-600)2014974-8$$a10.1007/s10519-010-9398-1$$gVol. 41, no. 3, p. 357 - 363$$n3$$p357-363$$q41:3<357 - 363$$tBehavior genetics$$v41$$x0001-8244$$y2011
000136241 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102774
000136241 8564_ $$uhttps://pub.dzne.de/record/136241/files/DZNE-2020-02563_Restricted.pdf
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