Journal Article

DZNE-2020-02563

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Increased levels of anxiety-related behaviors in a Tsc2 dominant negative transgenic mouse model of tuberous sclerosis.

Ehninger, D. (First author)DZNE* ; Silva, A. J.

2011
Springer Science + Business Media B.V Dordrecht [u.a.]

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Please use a persistent id in citations: doi:10.1007/s10519-010-9398-1

Abstract: Tuberous sclerosis (TSC) is a single-gene disorder caused by heterozygous mutations in the TSC1 or TSC2 gene. TSC is often associated with neurological (e.g., epilepsy), cognitive (intellectual disabilities, specific neuropsychological impairments) and behavioral pathologies (e.g., autism, attention deficit hyperactivity disorder). In addition, there is a high prevalence of psychiatric problems in TSC populations, including anxiety and mood disorders. To date, little is known about the pathogenetic bases of these associated psychiatric symptoms; for instance, it is unclear whether they are rooted in TSC-associated neurobiological alterations or whether they are secondary psychological phenomena (e.g., because individuals have to cope with the burden of the disease). Here, we report elevated levels of anxiety-related behaviors and mild deficits in two hippocampal-dependent learning tasks in a Tsc2 dominant negative transgenic mouse model of TSC. These findings establish a mouse model for TSC-related anxiety phenotypes and suggest that anxiety disorders in TSC have a biological foundation.

Keyword(s): Animals (MeSH) ; Anxiety: genetics (MeSH) ; Disease Models, Animal (MeSH) ; Female (MeSH) ; Genes, Dominant: genetics (MeSH) ; Genetic Carrier Screening (MeSH) ; Hippocampus: physiopathology (MeSH) ; Humans (MeSH) ; Learning Disabilities: genetics (MeSH) ; Learning Disabilities: physiopathology (MeSH) ; Male (MeSH) ; Memory Disorders: genetics (MeSH) ; Memory Disorders: physiopathology (MeSH) ; Mice (MeSH) ; Mice, Inbred C57BL (MeSH) ; Mice, Transgenic (MeSH) ; Phenotype (MeSH) ; Tuberous Sclerosis: genetics (MeSH) ; Tuberous Sclerosis: physiopathology (MeSH) ; Tuberous Sclerosis Complex 2 Protein (MeSH) ; Tumor Suppressor Proteins: genetics (MeSH) ; TSC2 protein, human ; Tsc2 protein, mouse ; Tuberous Sclerosis Complex 2 Protein ; Tumor Suppressor Proteins

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Contributing Institute(s):

1. Translational Biogerontology (AG Ehninger)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)

Appears in the scientific report 2011

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Current Contents - Social and Behavioral Sciences ; Ebsco Academic Search ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Social Sciences Citation Index ; Web of Science Core Collection ; Zoological Record

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