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@ARTICLE{Ehninger:136241,
      author       = {Ehninger, Dan and Silva, Alcino J},
      title        = {{I}ncreased levels of anxiety-related behaviors in a {T}sc2
                      dominant negative transgenic mouse model of tuberous
                      sclerosis.},
      journal      = {Behavior genetics},
      volume       = {41},
      number       = {3},
      issn         = {0001-8244},
      address      = {Dordrecht [u.a.]},
      publisher    = {Springer Science + Business Media B.V},
      reportid     = {DZNE-2020-02563},
      pages        = {357-363},
      year         = {2011},
      abstract     = {Tuberous sclerosis (TSC) is a single-gene disorder caused
                      by heterozygous mutations in the TSC1 or TSC2 gene. TSC is
                      often associated with neurological (e.g., epilepsy),
                      cognitive (intellectual disabilities, specific
                      neuropsychological impairments) and behavioral pathologies
                      (e.g., autism, attention deficit hyperactivity disorder). In
                      addition, there is a high prevalence of psychiatric problems
                      in TSC populations, including anxiety and mood disorders. To
                      date, little is known about the pathogenetic bases of these
                      associated psychiatric symptoms; for instance, it is unclear
                      whether they are rooted in TSC-associated neurobiological
                      alterations or whether they are secondary psychological
                      phenomena (e.g., because individuals have to cope with the
                      burden of the disease). Here, we report elevated levels of
                      anxiety-related behaviors and mild deficits in two
                      hippocampal-dependent learning tasks in a Tsc2 dominant
                      negative transgenic mouse model of TSC. These findings
                      establish a mouse model for TSC-related anxiety phenotypes
                      and suggest that anxiety disorders in TSC have a biological
                      foundation.},
      keywords     = {Animals / Anxiety: genetics / Disease Models, Animal /
                      Female / Genes, Dominant: genetics / Genetic Carrier
                      Screening / Hippocampus: physiopathology / Humans / Learning
                      Disabilities: genetics / Learning Disabilities:
                      physiopathology / Male / Memory Disorders: genetics / Memory
                      Disorders: physiopathology / Mice / Mice, Inbred C57BL /
                      Mice, Transgenic / Phenotype / Tuberous Sclerosis: genetics
                      / Tuberous Sclerosis: physiopathology / Tuberous Sclerosis
                      Complex 2 Protein / Tumor Suppressor Proteins: genetics /
                      TSC2 protein, human (NLM Chemicals) / Tsc2 protein, mouse
                      (NLM Chemicals) / Tuberous Sclerosis Complex 2 Protein (NLM
                      Chemicals) / Tumor Suppressor Proteins (NLM Chemicals)},
      cin          = {AG Ehninger},
      ddc          = {570},
      cid          = {I:(DE-2719)1013005},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:20882401},
      pmc          = {pmc:PMC3102774},
      doi          = {10.1007/s10519-010-9398-1},
      url          = {https://pub.dzne.de/record/136241},
}