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| Home > Publications Database > Increased levels of anxiety-related behaviors in a Tsc2 dominant negative transgenic mouse model of tuberous sclerosis. > print |
| 001 | 136241 | ||
| 005 | 20250416143148.0 | ||
| 024 | 7 | _ | |a 0005-7851 |2 ISSN |
| 024 | 7 | _ | |a 10.1007/s10519-010-9398-1 |2 doi |
| 024 | 7 | _ | |a pmid:20882401 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC3102774 |2 pmc |
| 024 | 7 | _ | |a 0001-8244 |2 ISSN |
| 024 | 7 | _ | |a 1573-3297 |2 ISSN |
| 037 | _ | _ | |a DZNE-2020-02563 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 570 |
| 100 | 1 | _ | |a Ehninger, Dan |0 P:(DE-2719)2289209 |b 0 |e First author |u dzne |
| 245 | _ | _ | |a Increased levels of anxiety-related behaviors in a Tsc2 dominant negative transgenic mouse model of tuberous sclerosis. |
| 260 | _ | _ | |a Dordrecht [u.a.] |c 2011 |b Springer Science + Business Media B.V |
| 264 | _ | 1 | |3 online |2 Crossref |b Springer Science and Business Media LLC |c 2010-09-30 |
| 264 | _ | 1 | |3 print |2 Crossref |b Springer Science and Business Media LLC |c 2011-05-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1744806670_2859 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Tuberous sclerosis (TSC) is a single-gene disorder caused by heterozygous mutations in the TSC1 or TSC2 gene. TSC is often associated with neurological (e.g., epilepsy), cognitive (intellectual disabilities, specific neuropsychological impairments) and behavioral pathologies (e.g., autism, attention deficit hyperactivity disorder). In addition, there is a high prevalence of psychiatric problems in TSC populations, including anxiety and mood disorders. To date, little is known about the pathogenetic bases of these associated psychiatric symptoms; for instance, it is unclear whether they are rooted in TSC-associated neurobiological alterations or whether they are secondary psychological phenomena (e.g., because individuals have to cope with the burden of the disease). Here, we report elevated levels of anxiety-related behaviors and mild deficits in two hippocampal-dependent learning tasks in a Tsc2 dominant negative transgenic mouse model of TSC. These findings establish a mouse model for TSC-related anxiety phenotypes and suggest that anxiety disorders in TSC have a biological foundation. |
| 536 | _ | _ | |a 342 - Disease Mechanisms and Model Systems (POF3-342) |0 G:(DE-HGF)POF3-342 |c POF3-342 |f POF III |x 0 |
| 542 | _ | _ | |i 2010-09-30 |2 Crossref |u http://www.springer.com/tdm |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a TSC2 protein, human |2 NLM Chemicals |
| 650 | _ | 7 | |a Tsc2 protein, mouse |2 NLM Chemicals |
| 650 | _ | 7 | |a Tuberous Sclerosis Complex 2 Protein |2 NLM Chemicals |
| 650 | _ | 7 | |a Tumor Suppressor Proteins |2 NLM Chemicals |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Anxiety: genetics |2 MeSH |
| 650 | _ | 2 | |a Disease Models, Animal |2 MeSH |
| 650 | _ | 2 | |a Female |2 MeSH |
| 650 | _ | 2 | |a Genes, Dominant: genetics |2 MeSH |
| 650 | _ | 2 | |a Genetic Carrier Screening |2 MeSH |
| 650 | _ | 2 | |a Hippocampus: physiopathology |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Learning Disabilities: genetics |2 MeSH |
| 650 | _ | 2 | |a Learning Disabilities: physiopathology |2 MeSH |
| 650 | _ | 2 | |a Male |2 MeSH |
| 650 | _ | 2 | |a Memory Disorders: genetics |2 MeSH |
| 650 | _ | 2 | |a Memory Disorders: physiopathology |2 MeSH |
| 650 | _ | 2 | |a Mice |2 MeSH |
| 650 | _ | 2 | |a Mice, Inbred C57BL |2 MeSH |
| 650 | _ | 2 | |a Mice, Transgenic |2 MeSH |
| 650 | _ | 2 | |a Phenotype |2 MeSH |
| 650 | _ | 2 | |a Tuberous Sclerosis: genetics |2 MeSH |
| 650 | _ | 2 | |a Tuberous Sclerosis: physiopathology |2 MeSH |
| 650 | _ | 2 | |a Tuberous Sclerosis Complex 2 Protein |2 MeSH |
| 650 | _ | 2 | |a Tumor Suppressor Proteins: genetics |2 MeSH |
| 700 | 1 | _ | |a Silva, Alcino J |0 P:(DE-HGF)0 |b 1 |
| 773 | 1 | 8 | |a 10.1007/s10519-010-9398-1 |b : Springer Science and Business Media LLC, 2010-09-30 |n 3 |p 357-363 |3 journal-article |2 Crossref |t Behavior Genetics |v 41 |y 2010 |x 0001-8244 |
| 773 | _ | _ | |a 10.1007/s10519-010-9398-1 |g Vol. 41, no. 3, p. 357 - 363 |0 PERI:(DE-600)2014974-8 |n 3 |q 41:3<357 - 363 |p 357-363 |t Behavior genetics |v 41 |y 2011 |x 0001-8244 |
| 856 | 7 | _ | |2 Pubmed Central |u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102774 |
| 856 | 4 | _ | |u https://pub.dzne.de/record/136241/files/DZNE-2020-02563_Restricted.pdf |
| 856 | 4 | _ | |u https://pub.dzne.de/record/136241/files/DZNE-2020-02563_Restricted.pdf?subformat=pdfa |x pdfa |
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