Journal Article (Review Article)

DZNE-2020-02626

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Role of astrocytes in neurovascular coupling.

Petzold, G. C. (First author)DZNE* ; Murthy, V. N.

2011
Elsevier New York, NY

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Please use a persistent id in citations: doi:10.1016/j.neuron.2011.08.009

Abstract: Neural activity is intimately tied to blood flow in the brain. This coupling is specific enough in space and time that modern imaging methods use local hemodynamics as a measure of brain activity. In this review, we discuss recent evidence indicating that neuronal activity is coupled to local blood flow changes through an intermediary, the astrocyte. We highlight unresolved issues regarding the role of astrocytes and propose ways to address them using novel techniques. Our focus is on cellular level analysis in vivo, but we also relate mechanistic insights gained from ex vivo experiments to native tissue. We also review some strategies to harness advances in optical and genetic methods to study neurovascular coupling in the intact brain.

Keyword(s): Animals (MeSH) ; Astrocytes: physiology (MeSH) ; Blood Vessels: cytology (MeSH) ; Blood Vessels: physiology (MeSH) ; Brain: blood supply (MeSH) ; Brain: cytology (MeSH) ; Brain: physiology (MeSH) ; Cerebrovascular Circulation: physiology (MeSH) ; Humans (MeSH) ; Models, Biological (MeSH) ; Neurons: physiology (MeSH) ; Synapses: physiology (MeSH)

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Contributing Institute(s):

1. Vascular Neurology (AG Petzold ; AG Petzold)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)

Appears in the scientific report 2011

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 10 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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