TY  - JOUR
AU  - Koppelmans, Vincent
AU  - Schagen, Sanne B
AU  - Poels, Mariëlle M F
AU  - Boogerd, Willem
AU  - Seynaeve, Caroline
AU  - van der Lugt, Aad
AU  - Breteler, Monique M B
TI  - Incidental findings on brain Magnetic Resonance Imaging in long-term survivors of breast cancer treated with adjuvant chemotherapy.
JO  - European journal of cancer
VL  - 47
IS  - 17
SN  - 0959-8049
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - DZNE-2020-02693
SP  - 2531-2536
PY  - 2011
AB  - Incidental brain findings defined as previously undetected abnormalities of potential clinical relevance that are unexpectedly discovered at brain imaging and are unrelated to the purpose of the examination are common in the general population. Because it is unclear whether the prevalence of incidental findings in breast cancer patients treated with chemotherapy is different to that in the general population, we compared the prevalence in breast cancer survivors treated with chemotherapy to that in a population-based sample of women without a history of any cancer.Structural brain MRI (1.5T) was performed in 191 female CMF (Cyclophosphamide, Methotrexate, 5-Fluorouracil) chemotherapy-exposed breast cancer survivors. A reference group of 1590 women without a history of cancer was sampled from a population-based cohort study. All participants were aged 50 to 80 years. Five trained reviewers recorded the brain abnormalities. Two experienced neuro-radiologists reviewed the incidental findings.The cancer survivors had completed chemotherapy on average 21 years before. Of the 191 subjects, 2.6
KW  - Aged
KW  - Aged, 80 and over
KW  - Antineoplastic Agents: therapeutic use
KW  - Antineoplastic Combined Chemotherapy Protocols: administration & dosage
KW  - Breast Neoplasms: complications
KW  - Breast Neoplasms: drug therapy
KW  - Chemotherapy, Adjuvant
KW  - Cyclophosphamide: administration & dosage
KW  - Female
KW  - Fluorouracil: administration & dosage
KW  - Humans
KW  - Incidence
KW  - Incidental Findings
KW  - Intracranial Aneurysm: diagnosis
KW  - Intracranial Aneurysm: epidemiology
KW  - Magnetic Resonance Imaging
KW  - Meningioma: diagnosis
KW  - Meningioma: epidemiology
KW  - Methotrexate: administration & dosage
KW  - Middle Aged
KW  - Neoplasms, Second Primary: diagnosis
KW  - Neoplasms, Second Primary: epidemiology
KW  - Pituitary Neoplasms: diagnosis
KW  - Pituitary Neoplasms: epidemiology
KW  - Survivors
KW  - Antineoplastic Agents (NLM Chemicals)
KW  - Cyclophosphamide (NLM Chemicals)
KW  - Fluorouracil (NLM Chemicals)
KW  - Methotrexate (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:21745734
DO  - DOI:10.1016/j.ejca.2011.06.026
UR  - https://pub.dzne.de/record/136371
ER  -