Journal Article

DZNE-2020-02693

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Incidental findings on brain Magnetic Resonance Imaging in long-term survivors of breast cancer treated with adjuvant chemotherapy.

Koppelmans, V. ; Schagen, S. B. (Corresponding author) ; Poels, M. M. F. ; Boogerd, W. ; Seynaeve, C. ; van der Lugt, A. ; Breteler, M. M. B. (Last author)DZNE*

2011
Elsevier Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.ejca.2011.06.026

Abstract: Incidental brain findings defined as previously undetected abnormalities of potential clinical relevance that are unexpectedly discovered at brain imaging and are unrelated to the purpose of the examination are common in the general population. Because it is unclear whether the prevalence of incidental findings in breast cancer patients treated with chemotherapy is different to that in the general population, we compared the prevalence in breast cancer survivors treated with chemotherapy to that in a population-based sample of women without a history of any cancer.Structural brain MRI (1.5T) was performed in 191 female CMF (Cyclophosphamide, Methotrexate, 5-Fluorouracil) chemotherapy-exposed breast cancer survivors. A reference group of 1590 women without a history of cancer was sampled from a population-based cohort study. All participants were aged 50 to 80 years. Five trained reviewers recorded the brain abnormalities. Two experienced neuro-radiologists reviewed the incidental findings.The cancer survivors had completed chemotherapy on average 21 years before. Of the 191 subjects, 2.6% had an aneurysm and 3.7% had a meningioma. The prevalence of meningiomas and aneurysms was not different between the groups. The prevalence of pituitary macro adenomas in the breast cancer survivors (1.6%) was higher than that in the reference group (0.1%) (OR=23.7; 95% CI 2.3-245.8).Contrary to commonly held opinions, we did not observe an increased prevalence of meningiomas in cancer survivors. Breast cancer survivors previously treated with chemotherapy are more likely to develop pituitary adenomas than persons without a history of cancer and chemotherapy treatment.

Keyword(s): Aged (MeSH) ; Aged, 80 and over (MeSH) ; Antineoplastic Agents: therapeutic use (MeSH) ; Antineoplastic Combined Chemotherapy Protocols: administration & dosage (MeSH) ; Breast Neoplasms: complications (MeSH) ; Breast Neoplasms: drug therapy (MeSH) ; Chemotherapy, Adjuvant (MeSH) ; Cyclophosphamide: administration & dosage (MeSH) ; Female (MeSH) ; Fluorouracil: administration & dosage (MeSH) ; Humans (MeSH) ; Incidence (MeSH) ; Incidental Findings (MeSH) ; Intracranial Aneurysm: diagnosis (MeSH) ; Intracranial Aneurysm: epidemiology (MeSH) ; Magnetic Resonance Imaging (MeSH) ; Meningioma: diagnosis (MeSH) ; Meningioma: epidemiology (MeSH) ; Methotrexate: administration & dosage (MeSH) ; Middle Aged (MeSH) ; Neoplasms, Second Primary: diagnosis (MeSH) ; Neoplasms, Second Primary: epidemiology (MeSH) ; Pituitary Neoplasms: diagnosis (MeSH) ; Pituitary Neoplasms: epidemiology (MeSH) ; Survivors (MeSH) ; Antineoplastic Agents ; Cyclophosphamide ; Fluorouracil ; Methotrexate

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Contributing Institute(s):

1. Population Health Sciences (AG Breteler)

Research Program(s):

1. 345 - Population Studies and Genetics (POF3-345) (POF3-345)

Appears in the scientific report 2011

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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