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@ARTICLE{Koppelmans:136371,
      author       = {Koppelmans, Vincent and Schagen, Sanne B and Poels,
                      Mariëlle M F and Boogerd, Willem and Seynaeve, Caroline and
                      van der Lugt, Aad and Breteler, Monique M B},
      title        = {{I}ncidental findings on brain {M}agnetic {R}esonance
                      {I}maging in long-term survivors of breast cancer treated
                      with adjuvant chemotherapy.},
      journal      = {European journal of cancer},
      volume       = {47},
      number       = {17},
      issn         = {0959-8049},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DZNE-2020-02693},
      pages        = {2531-2536},
      year         = {2011},
      abstract     = {Incidental brain findings defined as previously undetected
                      abnormalities of potential clinical relevance that are
                      unexpectedly discovered at brain imaging and are unrelated
                      to the purpose of the examination are common in the general
                      population. Because it is unclear whether the prevalence of
                      incidental findings in breast cancer patients treated with
                      chemotherapy is different to that in the general population,
                      we compared the prevalence in breast cancer survivors
                      treated with chemotherapy to that in a population-based
                      sample of women without a history of any cancer.Structural
                      brain MRI (1.5T) was performed in 191 female CMF
                      (Cyclophosphamide, Methotrexate, 5-Fluorouracil)
                      chemotherapy-exposed breast cancer survivors. A reference
                      group of 1590 women without a history of cancer was sampled
                      from a population-based cohort study. All participants were
                      aged 50 to 80 years. Five trained reviewers recorded the
                      brain abnormalities. Two experienced neuro-radiologists
                      reviewed the incidental findings.The cancer survivors had
                      completed chemotherapy on average 21 years before. Of the
                      191 subjects, $2.6\%$ had an aneurysm and $3.7\%$ had a
                      meningioma. The prevalence of meningiomas and aneurysms was
                      not different between the groups. The prevalence of
                      pituitary macro adenomas in the breast cancer survivors
                      $(1.6\%)$ was higher than that in the reference group
                      $(0.1\%)$ (OR=23.7; $95\%$ CI 2.3-245.8).Contrary to
                      commonly held opinions, we did not observe an increased
                      prevalence of meningiomas in cancer survivors. Breast cancer
                      survivors previously treated with chemotherapy are more
                      likely to develop pituitary adenomas than persons without a
                      history of cancer and chemotherapy treatment.},
      keywords     = {Aged / Aged, 80 and over / Antineoplastic Agents:
                      therapeutic use / Antineoplastic Combined Chemotherapy
                      Protocols: administration $\&$ dosage / Breast Neoplasms:
                      complications / Breast Neoplasms: drug therapy /
                      Chemotherapy, Adjuvant / Cyclophosphamide: administration
                      $\&$ dosage / Female / Fluorouracil: administration $\&$
                      dosage / Humans / Incidence / Incidental Findings /
                      Intracranial Aneurysm: diagnosis / Intracranial Aneurysm:
                      epidemiology / Magnetic Resonance Imaging / Meningioma:
                      diagnosis / Meningioma: epidemiology / Methotrexate:
                      administration $\&$ dosage / Middle Aged / Neoplasms, Second
                      Primary: diagnosis / Neoplasms, Second Primary: epidemiology
                      / Pituitary Neoplasms: diagnosis / Pituitary Neoplasms:
                      epidemiology / Survivors / Antineoplastic Agents (NLM
                      Chemicals) / Cyclophosphamide (NLM Chemicals) / Fluorouracil
                      (NLM Chemicals) / Methotrexate (NLM Chemicals)},
      cin          = {AG Breteler},
      ddc          = {610},
      cid          = {I:(DE-2719)1012001},
      pnm          = {345 - Population Studies and Genetics (POF3-345)},
      pid          = {G:(DE-HGF)POF3-345},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:21745734},
      doi          = {10.1016/j.ejca.2011.06.026},
      url          = {https://pub.dzne.de/record/136371},
}