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000136421 037__ $$aDZNE-2020-02743
000136421 041__ $$aEnglish
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000136421 1001_ $$0P:(DE-HGF)0$$aLövdén, Martin$$b0$$eCorresponding author
000136421 245__ $$aSpatial navigation training protects the hippocampus against age-related changes during early and late adulthood.
000136421 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2012
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000136421 520__ $$aIt is unknown whether lifestyle, including mental stimulation, and appropriate training interventions, may directly improve spatial navigation performance and its underlying neural substrates. Here we report that healthy younger and older men performing a cognitively demanding spatial navigation task every other day over 4 months display navigation-related gains in performance and stable hippocampal volumes that were maintained 4 months after termination of training. In contrast, control groups displayed volume decrements consistent with longitudinal estimates of age-related decline. Hippocampal barrier density, as indicated by mean diffusivity estimated from diffusion tensor imaging, showed a quadratic shape of increased density after training followed by a return to baseline in the right hippocampus, but declined in the control groups and in the left hippocampus. We conclude that sustained experiential demands on spatial ability protect hippocampal integrity against age-related decline. These results provide the first longitudinal evidence indicating that spatial navigation experience modifies hippocampal volumes in humans, and confirm epidemiological results suggesting that mental stimulation may have direct effects on neural integrity.
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000136421 650_2 $$2MeSH$$aAdult
000136421 650_2 $$2MeSH$$aAge Factors
000136421 650_2 $$2MeSH$$aAged
000136421 650_2 $$2MeSH$$aAging: pathology
000136421 650_2 $$2MeSH$$aAging: psychology
000136421 650_2 $$2MeSH$$aExercise Therapy: instrumentation
000136421 650_2 $$2MeSH$$aExercise Therapy: methods
000136421 650_2 $$2MeSH$$aFemale
000136421 650_2 $$2MeSH$$aHippocampus: pathology
000136421 650_2 $$2MeSH$$aHippocampus: physiopathology
000136421 650_2 $$2MeSH$$aHumans
000136421 650_2 $$2MeSH$$aMale
000136421 650_2 $$2MeSH$$aMemory Disorders: physiopathology
000136421 650_2 $$2MeSH$$aMemory Disorders: prevention & control
000136421 650_2 $$2MeSH$$aMemory Disorders: therapy
000136421 650_2 $$2MeSH$$aMiddle Aged
000136421 650_2 $$2MeSH$$aUser-Computer Interface
000136421 650_2 $$2MeSH$$aYoung Adult
000136421 7001_ $$aSchaefer, Sabine$$b1
000136421 7001_ $$aNoack, Hannes$$b2
000136421 7001_ $$aBodammer, Nils Christian$$b3
000136421 7001_ $$aKühn, Simone$$b4
000136421 7001_ $$0P:(DE-2719)2260426$$aHeinze, Hans-Jochen$$b5$$udzne
000136421 7001_ $$0P:(DE-2719)2000005$$aDüzel, Emrah$$b6$$udzne
000136421 7001_ $$aBäckman, Lars$$b7
000136421 7001_ $$aLindenberger, Ulman$$b8
000136421 77318 $$2Crossref$$3journal-article$$a10.1016/j.neurobiolaging.2011.02.013$$b : Elsevier BV, 2012-03-01$$n3$$p620.e9-620.e22$$tNeurobiology of Aging$$v33$$x0197-4580$$y2012
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