Journal Article

DZNE-2020-02743

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Spatial navigation training protects the hippocampus against age-related changes during early and late adulthood.

Lövdén, M. (Corresponding author) ; Schaefer, S. ; Noack, H. ; Bodammer, N. C. ; Kühn, S. ; Heinze, H.-J.DZNE* ; Düzel, E.DZNE* ; Bäckman, L. ; Lindenberger, U.

2012
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.neurobiolaging.2011.02.013

Abstract: It is unknown whether lifestyle, including mental stimulation, and appropriate training interventions, may directly improve spatial navigation performance and its underlying neural substrates. Here we report that healthy younger and older men performing a cognitively demanding spatial navigation task every other day over 4 months display navigation-related gains in performance and stable hippocampal volumes that were maintained 4 months after termination of training. In contrast, control groups displayed volume decrements consistent with longitudinal estimates of age-related decline. Hippocampal barrier density, as indicated by mean diffusivity estimated from diffusion tensor imaging, showed a quadratic shape of increased density after training followed by a return to baseline in the right hippocampus, but declined in the control groups and in the left hippocampus. We conclude that sustained experiential demands on spatial ability protect hippocampal integrity against age-related decline. These results provide the first longitudinal evidence indicating that spatial navigation experience modifies hippocampal volumes in humans, and confirm epidemiological results suggesting that mental stimulation may have direct effects on neural integrity.

Keyword(s): Adult (MeSH) ; Age Factors (MeSH) ; Aged (MeSH) ; Aging: pathology (MeSH) ; Aging: psychology (MeSH) ; Exercise Therapy: instrumentation (MeSH) ; Exercise Therapy: methods (MeSH) ; Female (MeSH) ; Hippocampus: pathology (MeSH) ; Hippocampus: physiopathology (MeSH) ; Humans (MeSH) ; Male (MeSH) ; Memory Disorders: physiopathology (MeSH) ; Memory Disorders: prevention & control (MeSH) ; Memory Disorders: therapy (MeSH) ; Middle Aged (MeSH) ; User-Computer Interface (MeSH) ; Young Adult (MeSH)

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Contributing Institute(s):

1. U Clinical Researchers - Magdeburg (U Clinical Researchers - Magdeburg)
2. Clinical Neurophysiology and Memory (AG Düzel)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)

Appears in the scientific report 2012

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Database coverage:
; ; ; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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