Home > Publications Database > Spatial navigation training protects the hippocampus against age-related changes during early and late adulthood. > print

001     136421
005     20240321220051.0
024 7 _ |a 10.1016/j.neurobiolaging.2011.02.013
|2 doi
024 7 _ |a pmid:21497950
|2 pmid
024 7 _ |a 0197-4580
|2 ISSN
024 7 _ |a 1558-1497
|2 ISSN
024 7 _ |a altmetric:565530
|2 altmetric
037 _ _ |a DZNE-2020-02743
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Lövdén, Martin
|0 P:(DE-HGF)0
|b 0
|e Corresponding author
245 _ _ |a Spatial navigation training protects the hippocampus against age-related changes during early and late adulthood.
260 _ _ |a Amsterdam [u.a.]
|c 2012
|b Elsevier Science
264 _ 1 |3 print
|2 Crossref
|b Elsevier BV
|c 2012-03-01
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1709648992_29110
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a It is unknown whether lifestyle, including mental stimulation, and appropriate training interventions, may directly improve spatial navigation performance and its underlying neural substrates. Here we report that healthy younger and older men performing a cognitively demanding spatial navigation task every other day over 4 months display navigation-related gains in performance and stable hippocampal volumes that were maintained 4 months after termination of training. In contrast, control groups displayed volume decrements consistent with longitudinal estimates of age-related decline. Hippocampal barrier density, as indicated by mean diffusivity estimated from diffusion tensor imaging, showed a quadratic shape of increased density after training followed by a return to baseline in the right hippocampus, but declined in the control groups and in the left hippocampus. We conclude that sustained experiential demands on spatial ability protect hippocampal integrity against age-related decline. These results provide the first longitudinal evidence indicating that spatial navigation experience modifies hippocampal volumes in humans, and confirm epidemiological results suggesting that mental stimulation may have direct effects on neural integrity.
536 _ _ |a 344 - Clinical and Health Care Research (POF3-344)
|0 G:(DE-HGF)POF3-344
|c POF3-344
|f POF III
|x 0
542 _ _ |i 2012-03-01
|2 Crossref
|u https://www.elsevier.com/tdm/userlicense/1.0/
542 _ _ |i 2013-07-16
|2 Crossref
|u http://creativecommons.org/licenses/by-nc-nd/3.0/
588 _ _ |a Dataset connected to CrossRef, PubMed,
650 _ 2 |a Adult
|2 MeSH
650 _ 2 |a Age Factors
|2 MeSH
650 _ 2 |a Aged
|2 MeSH
650 _ 2 |a Aging: pathology
|2 MeSH
650 _ 2 |a Aging: psychology
|2 MeSH
650 _ 2 |a Exercise Therapy: instrumentation
|2 MeSH
650 _ 2 |a Exercise Therapy: methods
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Hippocampus: pathology
|2 MeSH
650 _ 2 |a Hippocampus: physiopathology
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Memory Disorders: physiopathology
|2 MeSH
650 _ 2 |a Memory Disorders: prevention & control
|2 MeSH
650 _ 2 |a Memory Disorders: therapy
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a User-Computer Interface
|2 MeSH
650 _ 2 |a Young Adult
|2 MeSH
700 1 _ |a Schaefer, Sabine
|b 1
700 1 _ |a Noack, Hannes
|b 2
700 1 _ |a Bodammer, Nils Christian
|b 3
700 1 _ |a Kühn, Simone
|b 4
700 1 _ |a Heinze, Hans-Jochen
|0 P:(DE-2719)2260426
|b 5
|u dzne
700 1 _ |a Düzel, Emrah
|0 P:(DE-2719)2000005
|b 6
|u dzne
700 1 _ |a Bäckman, Lars
|b 7
700 1 _ |a Lindenberger, Ulman
|b 8
773 1 8 |a 10.1016/j.neurobiolaging.2011.02.013
|b : Elsevier BV, 2012-03-01
|n 3
|p 620.e9-620.e22
|3 journal-article
|2 Crossref
|t Neurobiology of Aging
|v 33
|y 2012
|x 0197-4580
773 _ _ |a 10.1016/j.neurobiolaging.2011.02.013
|g Vol. 33, no. 3, p. 620.e9 - 620.e22
|0 PERI:(DE-600)1498414-3
|n 3
|q 33:3<620.e9 - 620.e22
|p 620.e9-620.e22
|t Neurobiology of aging
|v 33
|y 2012
|x 0197-4580
856 4 _ |u https://pub.dzne.de/record/136421/files/DZNE-2020-02743.pdf
|y OpenAccess
856 4 _ |u https://pub.dzne.de/record/136421/files/DZNE-2020-02743.pdf?subformat=pdfa
|x pdfa
|y OpenAccess
909 C O |o oai:pub.dzne.de:136421
|p openaire
|p open_access
|p VDB
|p driver
|p dnbdelivery
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 5
|6 P:(DE-2719)2260426
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 6
|6 P:(DE-2719)2000005
913 1 _ |a DE-HGF
|b Gesundheit
|l Erkrankungen des Nervensystems
|1 G:(DE-HGF)POF3-340
|0 G:(DE-HGF)POF3-344
|3 G:(DE-HGF)POF3
|2 G:(DE-HGF)POF3-300
|4 G:(DE-HGF)POF
|v Clinical and Health Care Research
|x 0
914 1 _ |y 2012
915 _ _ |a Creative Commons Attribution-NonCommercial-NoDerivs CC BY-NC-ND 3.0
|0 LIC:(DE-HGF)CCBYNCND3
|2 HGFVOC
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1030
|2 StatID
|b Current Contents - Life Sciences
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0600
|2 StatID
|b Ebsco Academic Search
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b NEUROBIOL AGING : 2017
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
915 _ _ |a WoS
|0 StatID:(DE-HGF)0110
|2 StatID
|b Science Citation Index
915 _ _ |a WoS
|0 StatID:(DE-HGF)0111
|2 StatID
|b Science Citation Index Expanded
915 _ _ |a IF < 5
|0 StatID:(DE-HGF)9900
|2 StatID
915 _ _ |a OpenAccess
|0 StatID:(DE-HGF)0510
|2 StatID
915 _ _ |a Peer Review
|0 StatID:(DE-HGF)0030
|2 StatID
|b ASC
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0310
|2 StatID
|b NCBI Molecular Biology Database
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1050
|2 StatID
|b BIOSIS Previews
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
915 _ _ |a Nationallizenz
|0 StatID:(DE-HGF)0420
|2 StatID
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
920 1 _ |0 I:(DE-2719)7000000
|k U Clinical Researchers - Magdeburg
|l U Clinical Researchers - Magdeburg
|x 0
920 1 _ |0 I:(DE-2719)5000006
|k AG Düzel
|l Clinical Neurophysiology and Memory
|x 1
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a I:(DE-2719)7000000
980 _ _ |a I:(DE-2719)5000006
980 _ _ |a UNRESTRICTED
980 1 _ |a FullTexts

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21