Journal Article

DZNE-2020-02744

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Genome-wide association study of vascular dementia.

Schrijvers, E. M. C. ; Schürmann, B. ; Koudstaal, P. J. ; van den Bussche, H. ; Van Duijn, C. M. ; Hentschel, F. ; Heun, R. ; Hofman, A. ; Jessen, F. ; Kölsch, H. ; Kornhuber, J. ; Peters, O. ; Rivadeneira, F. ; Rüther, E. ; Uitterlinden, A. G. ; Riedel-Heller, S. ; Dichgans, M. ; Wiltfang, J. ; Maier, W. ; Breteler, M. M. B.DZNE* ; Ikram, M. A. (Corresponding author)

2012
Lippincott Williams & Wilkins Philadelphia, Pa.

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Please use a persistent id in citations: doi:10.1161/STROKEAHA.111.628768

Abstract: Most studies investigating the genetics of dementia have focused on Alzheimer disease, but little is known about the genetics of vascular dementia. The aim of our study was to identify new loci associated with vascular dementia.We performed a genome-wide association study in the Rotterdam Study, a large prospective population-based cohort study in the Netherlands. We sought to replicate genome-wide significant loci in 2 independent replication samples.In the discovery analysis of 5700 dementia-free individuals, 67 patients developed incident vascular dementia over a mean follow-up time of 9.3 ± 3.2 years. We showed genome-wide significance for rs12007229, which is located on the X chromosome near the androgen receptor gene (OR, 3.7; 95% CI, 2.3-5.8, per copy of the minor allele; P=1.3 × 10(-8)). This association was further confirmed in 2 independent populations (probability value of combined replication samples=0.024).Our study shows a novel genetic locus for vascular dementia on the X chromosome. Further replication of this finding is required.

Keyword(s): Aged (MeSH) ; Alleles (MeSH) ; Chromosomes, Human: genetics (MeSH) ; Chromosomes, Human, X: genetics (MeSH) ; Cohort Studies (MeSH) ; DNA: genetics (MeSH) ; Dementia, Vascular: epidemiology (MeSH) ; Dementia, Vascular: genetics (MeSH) ; Female (MeSH) ; Follow-Up Studies (MeSH) ; Genome-Wide Association Study (MeSH) ; Genotype (MeSH) ; Germany: epidemiology (MeSH) ; Humans (MeSH) ; Male (MeSH) ; Middle Aged (MeSH) ; Netherlands: epidemiology (MeSH) ; Polymorphism, Single Nucleotide (MeSH) ; Population (MeSH) ; Receptors, Androgen: genetics (MeSH) ; Sex Factors (MeSH) ; Receptors, Androgen ; DNA

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Contributing Institute(s):

1. Population Health Sciences (AG Breteler 1)

Research Program(s):

1. 345 - Population Studies and Genetics (POF3-345) (POF3-345)

Appears in the scientific report 2012

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Database coverage:
; Allianz-Lizenz ; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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