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000136481 0247_ $$2doi$$a10.1523/JNEUROSCI.0079-12.2012
000136481 0247_ $$2pmid$$apmid:22496552
000136481 0247_ $$2pmc$$apmc:PMC6622110
000136481 0247_ $$2ISSN$$a0270-6474
000136481 0247_ $$2ISSN$$a1529-2401
000136481 037__ $$aDZNE-2020-02803
000136481 041__ $$aEnglish
000136481 082__ $$a610
000136481 1001_ $$0P:(DE-HGF)0$$aBahari-Javan, Sanaz$$b0
000136481 245__ $$aHDAC1 regulates fear extinction in mice.
000136481 260__ $$aWashington, DC$$bSoc.57413$$c2012
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000136481 520__ $$aHistone acetylation has been implicated with the pathogenesis of neuropsychiatric disorders and targeting histone deacetylases (HDACs) using HDAC inhibitors was shown to be neuroprotective and to initiate neuroregenerative processes. However, little is known about the role of individual HDAC proteins during the pathogenesis of brain diseases. HDAC1 was found to be upregulated in patients suffering from neuropsychiatric diseases. Here, we show that virus-mediated overexpression of neuronal HDAC1 in the adult mouse hippocampus specifically affects the extinction of contextual fear memories, while other cognitive abilities were unaffected. In subsequent experiments we show that under physiological conditions, hippocampal HDAC1 is required for extinction learning via a mechanism that involves H3K9 deacetylation and subsequent trimethylation of target genes. In conclusion, our data show that hippocampal HDAC1 has a specific role in memory function.
000136481 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x0
000136481 542__ $$2Crossref$$i2012-10-11$$uhttps://creativecommons.org/licenses/by-nc-sa/4.0/
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000136481 650_7 $$2NLM Chemicals$$aBenzamides
000136481 650_7 $$2NLM Chemicals$$aHistone Deacetylase Inhibitors
000136481 650_7 $$2NLM Chemicals$$aPyridines
000136481 650_7 $$01ZNY4FKK9H$$2NLM Chemicals$$aentinostat
000136481 650_7 $$0EC 3.5.1.98$$2NLM Chemicals$$aHdac1 protein, mouse
000136481 650_7 $$0EC 3.5.1.98$$2NLM Chemicals$$aHistone Deacetylase 1
000136481 650_2 $$2MeSH$$aAcoustic Stimulation
000136481 650_2 $$2MeSH$$aAnimals
000136481 650_2 $$2MeSH$$aBenzamides: administration & dosage
000136481 650_2 $$2MeSH$$aBenzamides: pharmacology
000136481 650_2 $$2MeSH$$aBlotting, Western
000136481 650_2 $$2MeSH$$aChromatin Immunoprecipitation
000136481 650_2 $$2MeSH$$aElectroshock
000136481 650_2 $$2MeSH$$aExploratory Behavior: physiology
000136481 650_2 $$2MeSH$$aExtinction, Psychological: physiology
000136481 650_2 $$2MeSH$$aFear: physiology
000136481 650_2 $$2MeSH$$aHippocampus: cytology
000136481 650_2 $$2MeSH$$aHippocampus: drug effects
000136481 650_2 $$2MeSH$$aHistone Deacetylase 1: antagonists & inhibitors
000136481 650_2 $$2MeSH$$aHistone Deacetylase 1: genetics
000136481 650_2 $$2MeSH$$aHistone Deacetylase 1: physiology
000136481 650_2 $$2MeSH$$aHistone Deacetylase Inhibitors: administration & dosage
000136481 650_2 $$2MeSH$$aHistone Deacetylase Inhibitors: pharmacology
000136481 650_2 $$2MeSH$$aImmunohistochemistry
000136481 650_2 $$2MeSH$$aMale
000136481 650_2 $$2MeSH$$aMaze Learning: physiology
000136481 650_2 $$2MeSH$$aMice
000136481 650_2 $$2MeSH$$aMice, Inbred C57BL
000136481 650_2 $$2MeSH$$aMicroinjections
000136481 650_2 $$2MeSH$$aNeurons: metabolism
000136481 650_2 $$2MeSH$$aPostural Balance: physiology
000136481 650_2 $$2MeSH$$aPyridines: administration & dosage
000136481 650_2 $$2MeSH$$aPyridines: pharmacology
000136481 650_2 $$2MeSH$$aReal-Time Polymerase Chain Reaction
000136481 650_2 $$2MeSH$$aRecognition, Psychology: physiology
000136481 650_2 $$2MeSH$$aReflex, Startle: physiology
000136481 650_2 $$2MeSH$$aSwimming: psychology
000136481 7001_ $$0P:(DE-HGF)0$$aMaddalena, Andrea$$b1
000136481 7001_ $$0P:(DE-HGF)0$$aKerimoglu, Cemil$$b2
000136481 7001_ $$0P:(DE-HGF)0$$aWittnam, Jessica$$b3
000136481 7001_ $$0P:(DE-HGF)0$$aHeld, Torsten$$b4
000136481 7001_ $$0P:(DE-HGF)0$$aBähr, Mathias$$b5
000136481 7001_ $$0P:(DE-HGF)0$$aBurkhardt, Susanne$$b6
000136481 7001_ $$0P:(DE-HGF)0$$aDelalle, Ivanna$$b7
000136481 7001_ $$0P:(DE-HGF)0$$aKügler, Sebastian$$b8
000136481 7001_ $$0P:(DE-2719)2000047$$aFischer, Andre$$b9$$udzne
000136481 7001_ $$0P:(DE-HGF)0$$aSananbenesi, Farahnaz$$b10$$eCorresponding author
000136481 77318 $$2Crossref$$3journal-article$$a10.1523/jneurosci.0079-12.2012$$bSociety for Neuroscience$$d2012-04-11$$n15$$p5062-5073$$tThe Journal of Neuroscience$$v32$$x0270-6474$$y2012
000136481 773__ $$0PERI:(DE-600)1475274-8$$a10.1523/JNEUROSCI.0079-12.2012$$gVol. 32, no. 15, p. 5062 - 5073$$n15$$p5062-5073$$q32:15<5062 - 5073$$tThe journal of neuroscience$$v32$$x0270-6474$$y2012
000136481 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC6622110
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000136481 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000047$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b9$$kDZNE
000136481 9131_ $$0G:(DE-HGF)POF3-342$$1G:(DE-HGF)POF3-340$$2G:(DE-HGF)POF3-300$$aDE-HGF$$bForschungsbereich Gesundheit$$lErkrankungen des Nervensystems$$vDisease Mechanisms and Model Systems$$x0
000136481 9141_ $$y2012
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