Journal Article

DZNE-2020-02803

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png HDAC1 regulates fear extinction in mice.

Bahari-Javan, S. ; Maddalena, A. ; Kerimoglu, C. ; Wittnam, J. ; Held, T. ; Bähr, M. ; Burkhardt, S. ; Delalle, I. ; Kügler, S. ; Fischer, A.DZNE* ; Sananbenesi, F. (Corresponding author)

2012
Soc.57413 Washington, DC

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Please use a persistent id in citations: doi:10.1523/JNEUROSCI.0079-12.2012

Abstract: Histone acetylation has been implicated with the pathogenesis of neuropsychiatric disorders and targeting histone deacetylases (HDACs) using HDAC inhibitors was shown to be neuroprotective and to initiate neuroregenerative processes. However, little is known about the role of individual HDAC proteins during the pathogenesis of brain diseases. HDAC1 was found to be upregulated in patients suffering from neuropsychiatric diseases. Here, we show that virus-mediated overexpression of neuronal HDAC1 in the adult mouse hippocampus specifically affects the extinction of contextual fear memories, while other cognitive abilities were unaffected. In subsequent experiments we show that under physiological conditions, hippocampal HDAC1 is required for extinction learning via a mechanism that involves H3K9 deacetylation and subsequent trimethylation of target genes. In conclusion, our data show that hippocampal HDAC1 has a specific role in memory function.

Keyword(s): Acoustic Stimulation (MeSH) ; Animals (MeSH) ; Benzamides: administration & dosage (MeSH) ; Benzamides: pharmacology (MeSH) ; Blotting, Western (MeSH) ; Chromatin Immunoprecipitation (MeSH) ; Electroshock (MeSH) ; Exploratory Behavior: physiology (MeSH) ; Extinction, Psychological: physiology (MeSH) ; Fear: physiology (MeSH) ; Hippocampus: cytology (MeSH) ; Hippocampus: drug effects (MeSH) ; Histone Deacetylase 1: antagonists & inhibitors (MeSH) ; Histone Deacetylase 1: genetics (MeSH) ; Histone Deacetylase 1: physiology (MeSH) ; Histone Deacetylase Inhibitors: administration & dosage (MeSH) ; Histone Deacetylase Inhibitors: pharmacology (MeSH) ; Immunohistochemistry (MeSH) ; Male (MeSH) ; Maze Learning: physiology (MeSH) ; Mice (MeSH) ; Mice, Inbred C57BL (MeSH) ; Microinjections (MeSH) ; Neurons: metabolism (MeSH) ; Postural Balance: physiology (MeSH) ; Pyridines: administration & dosage (MeSH) ; Pyridines: pharmacology (MeSH) ; Real-Time Polymerase Chain Reaction (MeSH) ; Recognition, Psychology: physiology (MeSH) ; Reflex, Startle: physiology (MeSH) ; Swimming: psychology (MeSH) ; Benzamides ; Histone Deacetylase Inhibitors ; Pyridines ; entinostat ; Hdac1 protein, mouse ; Histone Deacetylase 1

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Contributing Institute(s):

1. Epigenetics and Systems Medicine in Neurodegenerative Diseases (AG Fischer 1)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)

Appears in the scientific report 2012

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; PubMed Central ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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