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@ARTICLE{BahariJavan:136481,
      author       = {Bahari-Javan, Sanaz and Maddalena, Andrea and Kerimoglu,
                      Cemil and Wittnam, Jessica and Held, Torsten and Bähr,
                      Mathias and Burkhardt, Susanne and Delalle, Ivanna and
                      Kügler, Sebastian and Fischer, Andre and Sananbenesi,
                      Farahnaz},
      title        = {{HDAC}1 regulates fear extinction in mice.},
      journal      = {The journal of neuroscience},
      volume       = {32},
      number       = {15},
      issn         = {0270-6474},
      address      = {Washington, DC},
      publisher    = {Soc.57413},
      reportid     = {DZNE-2020-02803},
      pages        = {5062-5073},
      year         = {2012},
      abstract     = {Histone acetylation has been implicated with the
                      pathogenesis of neuropsychiatric disorders and targeting
                      histone deacetylases (HDACs) using HDAC inhibitors was shown
                      to be neuroprotective and to initiate neuroregenerative
                      processes. However, little is known about the role of
                      individual HDAC proteins during the pathogenesis of brain
                      diseases. HDAC1 was found to be upregulated in patients
                      suffering from neuropsychiatric diseases. Here, we show that
                      virus-mediated overexpression of neuronal HDAC1 in the adult
                      mouse hippocampus specifically affects the extinction of
                      contextual fear memories, while other cognitive abilities
                      were unaffected. In subsequent experiments we show that
                      under physiological conditions, hippocampal HDAC1 is
                      required for extinction learning via a mechanism that
                      involves H3K9 deacetylation and subsequent trimethylation of
                      target genes. In conclusion, our data show that hippocampal
                      HDAC1 has a specific role in memory function.},
      keywords     = {Acoustic Stimulation / Animals / Benzamides: administration
                      $\&$ dosage / Benzamides: pharmacology / Blotting, Western /
                      Chromatin Immunoprecipitation / Electroshock / Exploratory
                      Behavior: physiology / Extinction, Psychological: physiology
                      / Fear: physiology / Hippocampus: cytology / Hippocampus:
                      drug effects / Histone Deacetylase 1: antagonists $\&$
                      inhibitors / Histone Deacetylase 1: genetics / Histone
                      Deacetylase 1: physiology / Histone Deacetylase Inhibitors:
                      administration $\&$ dosage / Histone Deacetylase Inhibitors:
                      pharmacology / Immunohistochemistry / Male / Maze Learning:
                      physiology / Mice / Mice, Inbred C57BL / Microinjections /
                      Neurons: metabolism / Postural Balance: physiology /
                      Pyridines: administration $\&$ dosage / Pyridines:
                      pharmacology / Real-Time Polymerase Chain Reaction /
                      Recognition, Psychology: physiology / Reflex, Startle:
                      physiology / Swimming: psychology / Benzamides (NLM
                      Chemicals) / Histone Deacetylase Inhibitors (NLM Chemicals)
                      / Pyridines (NLM Chemicals) / entinostat (NLM Chemicals) /
                      Hdac1 protein, mouse (NLM Chemicals) / Histone Deacetylase 1
                      (NLM Chemicals)},
      cin          = {AG Fischer 1},
      ddc          = {610},
      cid          = {I:(DE-2719)1410002},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:22496552},
      pmc          = {pmc:PMC6622110},
      doi          = {10.1523/JNEUROSCI.0079-12.2012},
      url          = {https://pub.dzne.de/record/136481},
}