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| Home > Publications Database > HDAC1 regulates fear extinction in mice. > print |
| 001 | 136481 | ||
| 005 | 20240321220057.0 | ||
| 024 | 7 | _ | |a 10.1523/JNEUROSCI.0079-12.2012 |2 doi |
| 024 | 7 | _ | |a pmid:22496552 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC6622110 |2 pmc |
| 024 | 7 | _ | |a 0270-6474 |2 ISSN |
| 024 | 7 | _ | |a 1529-2401 |2 ISSN |
| 037 | _ | _ | |a DZNE-2020-02803 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Bahari-Javan, Sanaz |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a HDAC1 regulates fear extinction in mice. |
| 260 | _ | _ | |a Washington, DC |c 2012 |b Soc.57413 |
| 264 | _ | 1 | |3 online |2 Crossref |b Society for Neuroscience |c 2012-04-11 |
| 264 | _ | 1 | |3 print |2 Crossref |b Society for Neuroscience |c 2012-04-11 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1585319343_16438 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Histone acetylation has been implicated with the pathogenesis of neuropsychiatric disorders and targeting histone deacetylases (HDACs) using HDAC inhibitors was shown to be neuroprotective and to initiate neuroregenerative processes. However, little is known about the role of individual HDAC proteins during the pathogenesis of brain diseases. HDAC1 was found to be upregulated in patients suffering from neuropsychiatric diseases. Here, we show that virus-mediated overexpression of neuronal HDAC1 in the adult mouse hippocampus specifically affects the extinction of contextual fear memories, while other cognitive abilities were unaffected. In subsequent experiments we show that under physiological conditions, hippocampal HDAC1 is required for extinction learning via a mechanism that involves H3K9 deacetylation and subsequent trimethylation of target genes. In conclusion, our data show that hippocampal HDAC1 has a specific role in memory function. |
| 536 | _ | _ | |a 342 - Disease Mechanisms and Model Systems (POF3-342) |0 G:(DE-HGF)POF3-342 |c POF3-342 |f POF III |x 0 |
| 542 | _ | _ | |i 2012-10-11 |2 Crossref |u https://creativecommons.org/licenses/by-nc-sa/4.0/ |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Benzamides |2 NLM Chemicals |
| 650 | _ | 7 | |a Histone Deacetylase Inhibitors |2 NLM Chemicals |
| 650 | _ | 7 | |a Pyridines |2 NLM Chemicals |
| 650 | _ | 7 | |a entinostat |0 1ZNY4FKK9H |2 NLM Chemicals |
| 650 | _ | 7 | |a Hdac1 protein, mouse |0 EC 3.5.1.98 |2 NLM Chemicals |
| 650 | _ | 7 | |a Histone Deacetylase 1 |0 EC 3.5.1.98 |2 NLM Chemicals |
| 650 | _ | 2 | |a Acoustic Stimulation |2 MeSH |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Benzamides: administration & dosage |2 MeSH |
| 650 | _ | 2 | |a Benzamides: pharmacology |2 MeSH |
| 650 | _ | 2 | |a Blotting, Western |2 MeSH |
| 650 | _ | 2 | |a Chromatin Immunoprecipitation |2 MeSH |
| 650 | _ | 2 | |a Electroshock |2 MeSH |
| 650 | _ | 2 | |a Exploratory Behavior: physiology |2 MeSH |
| 650 | _ | 2 | |a Extinction, Psychological: physiology |2 MeSH |
| 650 | _ | 2 | |a Fear: physiology |2 MeSH |
| 650 | _ | 2 | |a Hippocampus: cytology |2 MeSH |
| 650 | _ | 2 | |a Hippocampus: drug effects |2 MeSH |
| 650 | _ | 2 | |a Histone Deacetylase 1: antagonists & inhibitors |2 MeSH |
| 650 | _ | 2 | |a Histone Deacetylase 1: genetics |2 MeSH |
| 650 | _ | 2 | |a Histone Deacetylase 1: physiology |2 MeSH |
| 650 | _ | 2 | |a Histone Deacetylase Inhibitors: administration & dosage |2 MeSH |
| 650 | _ | 2 | |a Histone Deacetylase Inhibitors: pharmacology |2 MeSH |
| 650 | _ | 2 | |a Immunohistochemistry |2 MeSH |
| 650 | _ | 2 | |a Male |2 MeSH |
| 650 | _ | 2 | |a Maze Learning: physiology |2 MeSH |
| 650 | _ | 2 | |a Mice |2 MeSH |
| 650 | _ | 2 | |a Mice, Inbred C57BL |2 MeSH |
| 650 | _ | 2 | |a Microinjections |2 MeSH |
| 650 | _ | 2 | |a Neurons: metabolism |2 MeSH |
| 650 | _ | 2 | |a Postural Balance: physiology |2 MeSH |
| 650 | _ | 2 | |a Pyridines: administration & dosage |2 MeSH |
| 650 | _ | 2 | |a Pyridines: pharmacology |2 MeSH |
| 650 | _ | 2 | |a Real-Time Polymerase Chain Reaction |2 MeSH |
| 650 | _ | 2 | |a Recognition, Psychology: physiology |2 MeSH |
| 650 | _ | 2 | |a Reflex, Startle: physiology |2 MeSH |
| 650 | _ | 2 | |a Swimming: psychology |2 MeSH |
| 700 | 1 | _ | |a Maddalena, Andrea |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Kerimoglu, Cemil |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Wittnam, Jessica |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Held, Torsten |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Bähr, Mathias |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Burkhardt, Susanne |0 P:(DE-HGF)0 |b 6 |
| 700 | 1 | _ | |a Delalle, Ivanna |0 P:(DE-HGF)0 |b 7 |
| 700 | 1 | _ | |a Kügler, Sebastian |0 P:(DE-HGF)0 |b 8 |
| 700 | 1 | _ | |a Fischer, Andre |0 P:(DE-2719)2000047 |b 9 |u dzne |
| 700 | 1 | _ | |a Sananbenesi, Farahnaz |0 P:(DE-HGF)0 |b 10 |e Corresponding author |
| 773 | 1 | 8 | |a 10.1523/jneurosci.0079-12.2012 |b Society for Neuroscience |d 2012-04-11 |n 15 |p 5062-5073 |3 journal-article |2 Crossref |t The Journal of Neuroscience |v 32 |y 2012 |x 0270-6474 |
| 773 | _ | _ | |a 10.1523/JNEUROSCI.0079-12.2012 |g Vol. 32, no. 15, p. 5062 - 5073 |0 PERI:(DE-600)1475274-8 |n 15 |q 32:15<5062 - 5073 |p 5062-5073 |t The journal of neuroscience |v 32 |y 2012 |x 0270-6474 |
| 856 | 7 | _ | |2 Pubmed Central |u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6622110 |
| 909 | C | O | |o oai:pub.dzne.de:136481 |p VDB |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 9 |6 P:(DE-2719)2000047 |
| 913 | 1 | _ | |a DE-HGF |b Forschungsbereich Gesundheit |l Erkrankungen des Nervensystems |1 G:(DE-HGF)POF3-340 |0 G:(DE-HGF)POF3-342 |2 G:(DE-HGF)POF3-300 |v Disease Mechanisms and Model Systems |x 0 |
| 914 | 1 | _ | |y 2012 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b J NEUROSCI : 2017 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0310 |2 StatID |b NCBI Molecular Biology Database |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0320 |2 StatID |b PubMed Central |
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| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0110 |2 StatID |b Science Citation Index |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0111 |2 StatID |b Science Citation Index Expanded |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |
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| 915 | _ | _ | |a IF >= 5 |0 StatID:(DE-HGF)9905 |2 StatID |b J NEUROSCI : 2017 |
| 920 | 1 | _ | |0 I:(DE-2719)1410002 |k AG Fischer 1 |l Epigenetics and Systems Medicine in Neurodegenerative Diseases |x 0 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-2719)1410002 |
| 980 | _ | _ | |a UNRESTRICTED |
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