%0 Journal Article
%A Taal, H Rob
%A Pourcain, Beate St
%A Thiering, Elisabeth
%A Das, Shikta
%A Mook-Kanamori, Dennis O
%A Warrington, Nicole M
%A Kaakinen, Marika
%A Kreiner-Møller, Eskil
%A Bradfield, Jonathan P
%A Freathy, Rachel M
%A Geller, Frank
%A Guxens, Mònica
%A Cousminer, Diana L
%A Kerkhof, Marjan
%A Timpson, Nicholas J
%A Ikram, M Arfan
%A Beilin, Lawrence J
%A Bønnelykke, Klaus
%A Buxton, Jessica L
%A Charoen, Pimphen
%A Chawes, Bo Lund Krogsgaard
%A Eriksson, Johan
%A Evans, David M
%A Hofman, Albert
%A Kemp, John P
%A Kim, Cecilia E
%A Klopp, Norman
%A Lahti, Jari
%A Lye, Stephen J
%A McMahon, George
%A Mentch, Frank D
%A Müller, Martina
%A O'Reilly, Paul F
%A Prokopenko, Inga
%A Rivadeneira, Fernando
%A Steegers, Eric A P
%A Sunyer, Jordi
%A Tiesler, Carla
%A Yaghootkar, Hanieh
%A Epidemiology, Cohorts for Heart and Aging Research in Genetic
%A Breteler, Monique M B
%A Debette, Stephanie
%A Fornage, Myriam
%A Gudnason, Vilmundur
%A Launer, Lenore J
%A van der Lugt, Aad
%A Mosley, Thomas H
%A Seshadri, Sudha
%A Smith, Albert V
%A Vernooij, Meike W
%A Epidemiology, Early Genetics & Lifecourse
%A Blakemore, Alexandra If
%A Chiavacci, Rosetta M
%A Feenstra, Bjarke
%A Fernandez-Benet, Julio
%A Grant, Struan F A
%A Hartikainen, Anna-Liisa
%A van der Heijden, Albert J
%A Iñiguez, Carmen
%A Lathrop, Mark
%A McArdle, Wendy L
%A Mølgaard, Anne
%A Newnham, John P
%A Palmer, Lyle J
%A Palotie, Aarno
%A Pouta, Annneli
%A Ring, Susan M
%A Sovio, Ulla
%A Standl, Marie
%A Uitterlinden, Andre G
%A Wichmann, H-Erich
%A Vissing, Nadja Hawwa
%A DeCarli, Charles
%A van Duijn, Cornelia M
%A McCarthy, Mark I
%A Koppelman, Gerard H
%A Estivill, Xavier
%A Hattersley, Andrew T
%A Melbye, Mads
%A Bisgaard, Hans
%A Pennell, Craig E
%A Widen, Elisabeth
%A Hakonarson, Hakon
%A Smith, George Davey
%A Heinrich, Joachim
%A Jarvelin, Marjo-Riitta
%A Genetics, Early Growth
%A Jaddoe, Vincent W V
%A Adair, Linda S
%A Ang, Wei
%A Atalay, Mustafa
%A van Beijsterveldt, Toos
%A Bergen, Nienke
%A Benke, Kelly
%A Berry, Diane
%A Bradfield, Jonathan P
%A Charoen, Pimphen
%A Coin, Lachlan
%A Cousminer, Diana L
%A Das, Shikta
%A Davis, Oliver S P
%A Elliott, Paul
%A Evans, David M
%A Feenstra, Bjarke
%A Flexeder, Claudia
%A Frayling, Tim
%A Freathy, Rachel M
%A Gaillard, Romy
%A Geller, Frank
%A Groen-Blokhuis, Maria
%A Goh, Liang-Kee
%A Guxens, Mònica
%A Haworth, Claire M A
%A Hadley, Dexter
%A Hedebrand, Johannes
%A Hinney, Anke
%A Hirschhorn, Joel N
%A Holloway, John W
%A Holst, Claus
%A Hottenga, Jouke Jan
%A Horikoshi, Momoko
%A Huikari, Ville
%A Hypponen, Elina
%A Iñiguez, Carmen
%A Kaakinen, Marika
%A Kilpeläinen, Tuomas O
%A Kirin, Mirna
%A Kowgier, Matthew
%A Lakka, Hanna-Maaria
%A Lange, Leslie A
%A Lawlor, Debbie A
%A Lehtimäki, Terho
%A Lewin, Alex
%A Lindgren, Cecilia
%A Lindi, Virpi
%A Maggi, Reedik
%A Marsh, Julie
%A Middeldorp, Christel
%A Millwood, Iona
%A Mook-Kanamori, Dennis O
%A Murray, Jeffrey C
%A Nivard, Michel
%A Nohr, Ellen Aagaard
%A Ntalla, Ioanna
%A Oken, Emily
%A O'Reilly, Paul F
%A Palmer, Lyle J
%A Panoutsopoulou, Kalliope
%A Pararajasingham, Jennifer
%A Prokopenko, Inga
%A Rodriguez, Alina
%A Salem, Rany M
%A Sebert, Sylvain
%A Siitonen, Niina
%A Sovio, Ulla
%A St Pourcain, Beate
%A Strachan, David P
%A Sunyer, Jordi
%A Taal, H Rob
%A Teo, Yik-Ying
%A Thiering, Elisabeth
%A Tiesler, Carla
%A Uitterlinden, Andre G
%A Valcárcel, Beatriz
%A Warrington, Nicole M
%A White, Scott
%A Willemsen, Gonneke
%A Yaghootkar, Hanieh
%A Zeggini, Eleftheria
%A Boomsma, Dorret I
%A Cooper, Cyrus
%A Estivill, Xavier
%A Gillman, Matthew
%A Grant, Struan F A
%A Hakonarson, Hakon
%A Hattersley, Andrew T
%A Heinrich, Joachim
%A Hocher, Berthold
%A Jaddoe, Vincent W V
%A Jarvelin, Marjo-Riitta
%A Lakka, Timo A
%A McCarthy, Mark I
%A Melbye, Mads
%A Mohlke, Karen L
%A Dedoussis, George V
%A Ong, Ken K
%A Pearson, Ewan R
%A Pennell, Craig E
%A Price, Thomas S
%A Power, Chris
%A Raitakari, Olli T
%A Saw, Seang-Mei
%A Scherag, Andre
%A Simell, Olli
%A Sørensen, Thorkild I A
%A Timpson, Nicholas J
%A Widen, Elisabeth
%A Wilson, James F
%A Ang, Wei
%A van Beijsterveldt, Toos
%A Bergen, Nienke
%A Benke, Kelly
%A Berry, Diane
%A Bradfield, Jonathan P
%A Charoen, Pimphen
%A Coin, Lachlan
%A Cousminer, Diana L
%A Das, Shikta
%A Elliott, Paul
%A Evans, David M
%A Frayling, Tim
%A Freathy, Rachel M
%A Gaillard, Romy
%A Groen-Blokhuis, Maria
%A Guxens, Mònica
%A Hadley, Dexter
%A Hottenga, Jouke Jan
%A Huikari, Ville
%A Hypponen, Elina
%A Kaakinen, Marika
%A Kowgier, Matthew
%A Lawlor, Debbie A
%A Lewin, Alex
%A Lindgren, Cecilia
%A Marsh, Julie
%A Middeldorp, Christel
%A Millwood, Iona
%A Mook-Kanamori, Dennis O
%A Nivard, Michel
%A O'Reilly, Paul F
%A Palmer, Lyle J
%A Prokopenko, Inga
%A Rodriguez, Alina
%A Sebert, Sylvain
%A Sovio, Ulla
%A St Pourcain, Beate
%A Standl, Marie
%A Strachan, David P
%A Sunyer, Jordi
%A Taal, H Rob
%A Thiering, Elisabeth
%A Tiesler, Carla
%A Uitterlinden, Andre G
%A Valcárcel, Beatriz
%A Warrington, Nicole M
%A White, Scott
%A Willemsen, Gonneke
%A Yaghootkar, Hanieh
%A Boomsma, Dorret I
%A Estivill, Xavier
%A Grant, Struan F A
%A Hakonarson, Hakon
%A Hattersley, Andrew T
%A Heinrich, Joachim
%A Jaddoe, Vincent W V
%A Jarvelin, Marjo-Riitta
%A McCarthy, Mark I
%A Pennell, Craig E
%A Power, Chris
%A Timpson, Nicholas J
%A Widen, Elisabeth
%A Ikram, M Arfan
%A Fornage, Myriam
%A Smith, Albert V
%A Seshadri, Sudha
%A Schmidt, Reinhold
%A Debette, Stéphanie
%A Vrooman, Henri A
%A Ropele, Stefan
%A Sigurdsson, Sigurdur
%A Coker, Laura H
%A Longstreth, W. T.
%A Niessen, Wiro J
%A DeStefano, Anita L
%A Beiser, Alexa
%A Zijdenbos, Alex P
%A Struchalin, Maksim
%A Jack, Clifford R
%A Nalls, Mike A
%A Au, Rhoda
%A Hofman, Albert
%A Gudnason, Haukur
%A van der Lugt, Aad
%A Harris, Tamara B
%A Meeks, William M
%A Vernooij, Meike W
%A van Buchem, Mark A
%A Catellier, Diane
%A Gudnason, Vilmundur
%A Windham, B Gwen
%A Wolf, Philip A
%A van Duijn, Cornelia M
%A Mosley, Thomas H
%A Schmidt, Helena
%A Launer, Lenore J
%A Breteler, Monique M B
%A DeCarli, Charles
%T Common variants at 12q15 and 12q24 are associated with infant head circumference.
%J Nature genetics
%V 44
%N 5
%@ 1061-4036
%C London
%I Macmillan Publishers Limited, part of Springer Nature
%M DZNE-2020-02825
%P 532-538
%D 2012
%X To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 × 10(-9)) and rs1042725 on chromosome 12q15 (P = 2.8 × 10(-10)) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height, their effects on infant head circumference were largely independent of height (P = 3.8 × 10(-7) for rs7980687 and P = 1.3 × 10(-7) for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P = 3.9 × 10(-6)). SNPs correlated to the 17q21 signal have shown genome-wide association with adult intracranial volume, Parkinson's disease and other neurodegenerative diseases, indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life.
%K Chromosomes, Human, Pair 12: genetics
%K European Continental Ancestry Group: genetics
%K Female
%K Genetic Loci
%K Genetic Markers
%K Genome-Wide Association Study
%K Head: growth & development
%K Head: pathology
%K Humans
%K Infant
%K Male
%K Meta-Analysis as Topic
%K Polymorphism, Single Nucleotide: genetics
%K Pregnancy
%K Pregnancy Complications: etiology
%K Pregnancy Complications: pathology
%K Genetic Markers (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:22504419
%2 pmc:PMC3773913
%R 10.1038/ng.2238
%U https://pub.dzne.de/record/136503