Home > Publications Database > Common variants at 12q15 and 12q24 are associated with infant head circumference. > print

001     136503
005     20240321220059.0
024 7 _ |a 10.1038/ng.2238
|2 doi
024 7 _ |a pmid:22504419
|2 pmid
024 7 _ |a pmc:PMC3773913
|2 pmc
024 7 _ |a 1061-4036
|2 ISSN
024 7 _ |a 1546-1718
|2 ISSN
024 7 _ |a altmetric:698606
|2 altmetric
037 _ _ |a DZNE-2020-02825
041 _ _ |a English
082 _ _ |a 570
100 1 _ |a Taal, H Rob
|b 0
245 _ _ |a Common variants at 12q15 and 12q24 are associated with infant head circumference.
260 _ _ |a London
|c 2012
|b Macmillan Publishers Limited, part of Springer Nature
264 _ 1 |3 online
|2 Crossref
|b Springer Science and Business Media LLC
|c 2012-04-15
264 _ 1 |3 print
|2 Crossref
|b Springer Science and Business Media LLC
|c 2012-05-01
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1594197566_24855
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 × 10(-9)) and rs1042725 on chromosome 12q15 (P = 2.8 × 10(-10)) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height, their effects on infant head circumference were largely independent of height (P = 3.8 × 10(-7) for rs7980687 and P = 1.3 × 10(-7) for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P = 3.9 × 10(-6)). SNPs correlated to the 17q21 signal have shown genome-wide association with adult intracranial volume, Parkinson's disease and other neurodegenerative diseases, indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life.
536 _ _ |a 345 - Population Studies and Genetics (POF3-345)
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542 _ _ |i 2012-04-15
|2 Crossref
|u http://www.springer.com/tdm
588 _ _ |a Dataset connected to CrossRef, PubMed,
650 _ 7 |a Genetic Markers
|2 NLM Chemicals
650 _ 2 |a Chromosomes, Human, Pair 12: genetics
|2 MeSH
650 _ 2 |a European Continental Ancestry Group: genetics
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Genetic Loci
|2 MeSH
650 _ 2 |a Genetic Markers
|2 MeSH
650 _ 2 |a Genome-Wide Association Study
|2 MeSH
650 _ 2 |a Head: growth & development
|2 MeSH
650 _ 2 |a Head: pathology
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Infant
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Meta-Analysis as Topic
|2 MeSH
650 _ 2 |a Polymorphism, Single Nucleotide: genetics
|2 MeSH
650 _ 2 |a Pregnancy
|2 MeSH
650 _ 2 |a Pregnancy Complications: etiology
|2 MeSH
650 _ 2 |a Pregnancy Complications: pathology
|2 MeSH
700 1 _ |a Pourcain, Beate St
|b 1
700 1 _ |a Thiering, Elisabeth
|b 2
700 1 _ |a Das, Shikta
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700 1 _ |a Mook-Kanamori, Dennis O
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773 _ _ |a 10.1038/ng.2238
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|o 10.1093/brain/awh034
999 C 5 |a 10.1001/archpedi.1976.02120060027006
|9 -- missing cx lookup --
|2 Crossref
|o 10.1001/archpedi.1976.02120060027006
999 C 5 |a 10.1375/twin.13.4.370
|9 -- missing cx lookup --
|2 Crossref
|o 10.1375/twin.13.4.370
999 C 5 |a 10.1002/ajmg.a.32434
|9 -- missing cx lookup --
|2 Crossref
|o 10.1002/ajmg.a.32434
999 C 5 |a 10.1016/j.pneurobio.2009.11.002
|9 -- missing cx lookup --
|2 Crossref
|o 10.1016/j.pneurobio.2009.11.002
999 C 5 |a 10.1016/j.molmed.2006.06.006
|9 -- missing cx lookup --
|2 Crossref
|o 10.1016/j.molmed.2006.06.006
999 C 5 |a 10.1016/j.ajhg.2009.01.017
|9 -- missing cx lookup --
|2 Crossref
|o 10.1016/j.ajhg.2009.01.017
999 C 5 |a 10.1203/00006450-200003000-00006
|9 -- missing cx lookup --
|2 Crossref
|o 10.1203/00006450-200003000-00006
999 C 5 |a 10.1371/journal.pgen.1000952
|9 -- missing cx lookup --
|2 Crossref
|o 10.1371/journal.pgen.1000952
999 C 5 |a 10.1371/journal.pgen.1000214
|9 -- missing cx lookup --
|2 Crossref
|o 10.1371/journal.pgen.1000214
999 C 5 |a 10.1371/journal.pone.0010693
|9 -- missing cx lookup --
|2 Crossref
|o 10.1371/journal.pone.0010693
999 C 5 |a 10.1371/journal.pbio.0060107
|9 -- missing cx lookup --
|2 Crossref
|o 10.1371/journal.pbio.0060107
999 C 5 |a 10.1128/MCB.20.17.6300-6307.2000
|9 -- missing cx lookup --
|2 Crossref
|o 10.1128/MCB.20.17.6300-6307.2000
999 C 5 |a 10.1091/mbc.7.9.1455
|9 -- missing cx lookup --
|2 Crossref
|o 10.1091/mbc.7.9.1455
999 C 5 |a 10.1080/03014460600742062
|9 -- missing cx lookup --
|2 Crossref
|o 10.1080/03014460600742062
999 C 5 |y 1993
|2 Crossref
|o CA Coyle-Thompson 1993
999 C 5 |a 10.1158/1535-7163.MCT-06-0659
|9 -- missing cx lookup --
|2 Crossref
|o 10.1158/1535-7163.MCT-06-0659
999 C 5 |a 10.1038/nrc1186
|9 -- missing cx lookup --
|2 Crossref
|o 10.1038/nrc1186
999 C 5 |a 10.1086/427565
|9 -- missing cx lookup --
|2 Crossref
|o 10.1086/427565
999 C 5 |a 10.1038/376771a0
|9 -- missing cx lookup --
|2 Crossref
|o 10.1038/376771a0
999 C 5 |a 10.1038/ng.446
|9 -- missing cx lookup --
|2 Crossref
|o 10.1038/ng.446
999 C 5 |a 10.1210/en.2009-1039
|9 -- missing cx lookup --
|2 Crossref
|o 10.1210/en.2009-1039
999 C 5 |a 10.1074/jbc.R800013200
|9 -- missing cx lookup --
|2 Crossref
|o 10.1074/jbc.R800013200
999 C 5 |a 10.3233/JAD-2010-101011
|9 -- missing cx lookup --
|2 Crossref
|o 10.3233/JAD-2010-101011
999 C 5 |a 10.1046/j.1471-4159.2004.02320.x
|9 -- missing cx lookup --
|2 Crossref
|o 10.1046/j.1471-4159.2004.02320.x
999 C 5 |a 10.1136/jnnp.2003.015750
|9 -- missing cx lookup --
|2 Crossref
|o 10.1136/jnnp.2003.015750
999 C 5 |a 10.1002/humu.20785
|9 -- missing cx lookup --
|2 Crossref
|o 10.1002/humu.20785
999 C 5 |a 10.1093/bioinformatics/btp420
|9 -- missing cx lookup --
|2 Crossref
|o 10.1093/bioinformatics/btp420
999 C 5 |a 10.1111/j.0006-341X.1999.00997.x
|9 -- missing cx lookup --
|2 Crossref
|o 10.1111/j.0006-341X.1999.00997.x
999 C 5 |a 10.1136/bmj.327.7414.557
|9 -- missing cx lookup --
|2 Crossref
|o 10.1136/bmj.327.7414.557
999 C 5 |a 10.1002/uog.5225
|9 -- missing cx lookup --
|2 Crossref
|o 10.1002/uog.5225
999 C 5 |a 10.1161/CIRCGENETICS.108.829747
|9 -- missing cx lookup --
|2 Crossref
|o 10.1161/CIRCGENETICS.108.829747
999 C 5 |a 10.1016/j.neurobiolaging.2006.12.012
|9 -- missing cx lookup --
|2 Crossref
|o 10.1016/j.neurobiolaging.2006.12.012

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21