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000136729 0247_ $$2doi$$a10.1159/000342907
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000136729 0247_ $$2ISSN$$a0014-3022
000136729 0247_ $$2ISSN$$a1421-9913
000136729 037__ $$aDZNE-2020-03051
000136729 041__ $$aEnglish
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000136729 1001_ $$0P:(DE-HGF)0$$aFonteyn, E. M. R.$$b0
000136729 245__ $$aProspective analysis of falls in dominant ataxias.
000136729 260__ $$aBasel$$bKarger$$c2013
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000136729 520__ $$aIn a previous retrospective study, we demonstrated that falls are common and often injurious in dominant spinocerebellar ataxias (SCAs) and that nonataxia features play an important role in these falls. Retrospective surveys are plagued by recall bias for the presence and details of prior falls. We therefore sought to corroborate and extend these retrospective findings by means of a prospective extension of this fall study. 113 patients with SCA1, SCA2, SCA3 or SCA6, recruited from the EuroSCA natural history study, were asked to keep a fall diary in between their annual visits to the participating centres. Additionally, patients completed a detailed questionnaire about the first three falls, to identify specific fall circumstances. Relevant disease characteristics were retrieved from the EuroSCA registry. 84.1% of patients reported at least one fall during a time period of 12 months. Fall-related injuries were common and their frequency increased with that of falls. The presence of nonataxia symptoms was associated with a higher fall frequency. This study confirms that falls are a frequent and serious complication of SCA, and that the presence of nonataxia symptoms is an important etiological factor in its occurrence.
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000136729 650_2 $$2MeSH$$aAccidental Falls: statistics & numerical data
000136729 650_2 $$2MeSH$$aAdult
000136729 650_2 $$2MeSH$$aAged
000136729 650_2 $$2MeSH$$aAged, 80 and over
000136729 650_2 $$2MeSH$$aFemale
000136729 650_2 $$2MeSH$$aHumans
000136729 650_2 $$2MeSH$$aLongitudinal Studies
000136729 650_2 $$2MeSH$$aMale
000136729 650_2 $$2MeSH$$aMiddle Aged
000136729 650_2 $$2MeSH$$aPrevalence
000136729 650_2 $$2MeSH$$aProspective Studies
000136729 650_2 $$2MeSH$$aSpinocerebellar Ataxias: complications
000136729 650_2 $$2MeSH$$aSpinocerebellar Ataxias: epidemiology
000136729 650_2 $$2MeSH$$aSpinocerebellar Ataxias: genetics
000136729 7001_ $$0P:(DE-HGF)0$$aSchmitz-Hübsch, T.$$b1
000136729 7001_ $$0P:(DE-HGF)0$$aVerstappen, C. C. P.$$b2
000136729 7001_ $$0P:(DE-HGF)0$$aBaliko, L.$$b3
000136729 7001_ $$0P:(DE-HGF)0$$aBloem, B. R.$$b4
000136729 7001_ $$0P:(DE-HGF)0$$aBoesch, S.$$b5
000136729 7001_ $$0P:(DE-HGF)0$$aBunn, L.$$b6
000136729 7001_ $$0P:(DE-HGF)0$$aGiunti, P.$$b7
000136729 7001_ $$0P:(DE-HGF)0$$aGlobas, C.$$b8
000136729 7001_ $$0P:(DE-2719)2810314$$aKlockgether, T.$$b9$$udzne
000136729 7001_ $$0P:(DE-HGF)0$$aMelegh, B.$$b10
000136729 7001_ $$0P:(DE-HGF)0$$aPandolfo, M.$$b11
000136729 7001_ $$0P:(DE-2719)2810795$$aSchöls, L.$$b12$$udzne
000136729 7001_ $$0P:(DE-HGF)0$$aTimmann, D.$$b13
000136729 7001_ $$0P:(DE-HGF)0$$avan de Warrenburg, B. P. C.$$b14$$eCorresponding author
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