Journal Article

DZNE-2020-03051

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Prospective analysis of falls in dominant ataxias.

Fonteyn, E. M. R. ; Schmitz-Hübsch, T. ; Verstappen, C. C. P. ; Baliko, L. ; Bloem, B. R. ; Boesch, S. ; Bunn, L. ; Giunti, P. ; Globas, C. ; Klockgether, T.DZNE* ; Melegh, B. ; Pandolfo, M. ; Schöls, L.DZNE* ; Timmann, D. ; van de Warrenburg, B. P. C. (Corresponding author)

2013
Karger Basel

This record in other databases:    

Please use a persistent id in citations: doi:10.1159/000342907

Abstract: In a previous retrospective study, we demonstrated that falls are common and often injurious in dominant spinocerebellar ataxias (SCAs) and that nonataxia features play an important role in these falls. Retrospective surveys are plagued by recall bias for the presence and details of prior falls. We therefore sought to corroborate and extend these retrospective findings by means of a prospective extension of this fall study. 113 patients with SCA1, SCA2, SCA3 or SCA6, recruited from the EuroSCA natural history study, were asked to keep a fall diary in between their annual visits to the participating centres. Additionally, patients completed a detailed questionnaire about the first three falls, to identify specific fall circumstances. Relevant disease characteristics were retrieved from the EuroSCA registry. 84.1% of patients reported at least one fall during a time period of 12 months. Fall-related injuries were common and their frequency increased with that of falls. The presence of nonataxia symptoms was associated with a higher fall frequency. This study confirms that falls are a frequent and serious complication of SCA, and that the presence of nonataxia symptoms is an important etiological factor in its occurrence.

Keyword(s): Accidental Falls: statistics & numerical data (MeSH) ; Adult (MeSH) ; Aged (MeSH) ; Aged, 80 and over (MeSH) ; Female (MeSH) ; Humans (MeSH) ; Longitudinal Studies (MeSH) ; Male (MeSH) ; Middle Aged (MeSH) ; Prevalence (MeSH) ; Prospective Studies (MeSH) ; Spinocerebellar Ataxias: complications (MeSH) ; Spinocerebellar Ataxias: epidemiology (MeSH) ; Spinocerebellar Ataxias: genetics (MeSH)

---

Contributing Institute(s):

1. Clinical Neurogenetics (AG Schöls 1)
2. Patient studies (Patient studies, Bonn)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)
2. 345 - Population Studies and Genetics (POF3-345) (POF3-345)

Appears in the scientific report 2013

---

Database coverage:
; Allianz-Lizenz ; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; PubMed Central ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

---