%0 Journal Article
%A Stunden, H James
%A Latz, Eicke
%T PKR stirs up inflammasomes.
%J Cell research
%V 23
%N 2
%@ 1001-0602
%C [London]
%I Macmillan Publishers Limited, part of Springer Nature
%M DZNE-2020-03139
%P 168-170
%D 2013
%X Inflammasomes are multiprotein complexes that detect and respond to foreign and endogenous danger signals by activating caspase-1; active caspase-1, in turn, matures the pro-inflammatory IL-1β family cytokines by cleaving their pro-forms into the biologically active cytokines. The upstream mechanisms leading to inflammasome activation, in particular for the NRLP3 inflammasome, remain poorly understood. Lu and colleagues identify a new function of Protein Kinase R (PKR) for activating the NLRP1, NLRP3, NLRC4 and AIM2 inflammasomes, thus identifying a potential new target for treating inflammasome-mediated diseases.
%K Animals
%K Carrier Proteins: metabolism
%K Humans
%K Inflammasomes: metabolism
%K NLR Family, Pyrin Domain-Containing 3 Protein
%K Nitric Oxide: metabolism
%K Shock, Septic: prevention & control
%K Carrier Proteins (NLM Chemicals)
%K Inflammasomes (NLM Chemicals)
%K NLR Family, Pyrin Domain-Containing 3 Protein (NLM Chemicals)
%K Nlrp3 protein, mouse (NLM Chemicals)
%K Nitric Oxide (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:22945351
%2 pmc:PMC3567816
%R 10.1038/cr.2012.125
%U https://pub.dzne.de/record/136817