Journal Article (Editorial)

DZNE-2020-03139

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png PKR stirs up inflammasomes.

Stunden, H. J. ; Latz, E. (Last author)DZNE*

2013
Macmillan Publishers Limited, part of Springer Nature [London]

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Please use a persistent id in citations: doi:10.1038/cr.2012.125

Abstract: Inflammasomes are multiprotein complexes that detect and respond to foreign and endogenous danger signals by activating caspase-1; active caspase-1, in turn, matures the pro-inflammatory IL-1β family cytokines by cleaving their pro-forms into the biologically active cytokines. The upstream mechanisms leading to inflammasome activation, in particular for the NRLP3 inflammasome, remain poorly understood. Lu and colleagues identify a new function of Protein Kinase R (PKR) for activating the NLRP1, NLRP3, NLRC4 and AIM2 inflammasomes, thus identifying a potential new target for treating inflammasome-mediated diseases.

Keyword(s): Animals (MeSH) ; Carrier Proteins: metabolism (MeSH) ; Humans (MeSH) ; Inflammasomes: metabolism (MeSH) ; NLR Family, Pyrin Domain-Containing 3 Protein (MeSH) ; Nitric Oxide: metabolism (MeSH) ; Shock, Septic: prevention & control (MeSH) ; Carrier Proteins ; Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Nlrp3 protein, mouse ; Nitric Oxide

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Contributing Institute(s):

1. Innate Immunity in Neurodegeneration (AG Latz)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)

Appears in the scientific report 2013

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Database coverage:
; Allianz-Lizenz / DFG ; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; IF >= 15 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; PubMed Central ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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