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000136817 0247_ $$2ISSN$$a1748-7838
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000136817 041__ $$aEnglish
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000136817 1001_ $$0P:(DE-HGF)0$$aStunden, H James$$b0
000136817 245__ $$aPKR stirs up inflammasomes.
000136817 260__ $$a[London]$$bMacmillan Publishers Limited, part of Springer Nature$$c2013
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000136817 520__ $$aInflammasomes are multiprotein complexes that detect and respond to foreign and endogenous danger signals by activating caspase-1; active caspase-1, in turn, matures the pro-inflammatory IL-1β family cytokines by cleaving their pro-forms into the biologically active cytokines. The upstream mechanisms leading to inflammasome activation, in particular for the NRLP3 inflammasome, remain poorly understood. Lu and colleagues identify a new function of Protein Kinase R (PKR) for activating the NLRP1, NLRP3, NLRC4 and AIM2 inflammasomes, thus identifying a potential new target for treating inflammasome-mediated diseases.
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000136817 650_7 $$2NLM Chemicals$$aCarrier Proteins
000136817 650_7 $$2NLM Chemicals$$aInflammasomes
000136817 650_7 $$2NLM Chemicals$$aNLR Family, Pyrin Domain-Containing 3 Protein
000136817 650_7 $$2NLM Chemicals$$aNlrp3 protein, mouse
000136817 650_7 $$031C4KY9ESH$$2NLM Chemicals$$aNitric Oxide
000136817 650_2 $$2MeSH$$aAnimals
000136817 650_2 $$2MeSH$$aCarrier Proteins: metabolism
000136817 650_2 $$2MeSH$$aHumans
000136817 650_2 $$2MeSH$$aInflammasomes: metabolism
000136817 650_2 $$2MeSH$$aNLR Family, Pyrin Domain-Containing 3 Protein
000136817 650_2 $$2MeSH$$aNitric Oxide: metabolism
000136817 650_2 $$2MeSH$$aShock, Septic: prevention & control
000136817 7001_ $$0P:(DE-2719)2000062$$aLatz, Eicke$$b1$$eLast author$$udzne
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