TY  - JOUR
AU  - Stunden, H James
AU  - Latz, Eicke
TI  - PKR stirs up inflammasomes.
JO  - Cell research
VL  - 23
IS  - 2
SN  - 1001-0602
CY  - [London]
PB  - Macmillan Publishers Limited, part of Springer Nature
M1  - DZNE-2020-03139
SP  - 168-170
PY  - 2013
AB  - Inflammasomes are multiprotein complexes that detect and respond to foreign and endogenous danger signals by activating caspase-1; active caspase-1, in turn, matures the pro-inflammatory IL-1β family cytokines by cleaving their pro-forms into the biologically active cytokines. The upstream mechanisms leading to inflammasome activation, in particular for the NRLP3 inflammasome, remain poorly understood. Lu and colleagues identify a new function of Protein Kinase R (PKR) for activating the NLRP1, NLRP3, NLRC4 and AIM2 inflammasomes, thus identifying a potential new target for treating inflammasome-mediated diseases.
KW  - Animals
KW  - Carrier Proteins: metabolism
KW  - Humans
KW  - Inflammasomes: metabolism
KW  - NLR Family, Pyrin Domain-Containing 3 Protein
KW  - Nitric Oxide: metabolism
KW  - Shock, Septic: prevention & control
KW  - Carrier Proteins (NLM Chemicals)
KW  - Inflammasomes (NLM Chemicals)
KW  - NLR Family, Pyrin Domain-Containing 3 Protein (NLM Chemicals)
KW  - Nlrp3 protein, mouse (NLM Chemicals)
KW  - Nitric Oxide (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:22945351
C2  - pmc:PMC3567816
DO  - DOI:10.1038/cr.2012.125
UR  - https://pub.dzne.de/record/136817
ER  -