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@ARTICLE{Stunden:136817,
      author       = {Stunden, H James and Latz, Eicke},
      title        = {{PKR} stirs up inflammasomes.},
      journal      = {Cell research},
      volume       = {23},
      number       = {2},
      issn         = {1001-0602},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {DZNE-2020-03139},
      pages        = {168-170},
      year         = {2013},
      abstract     = {Inflammasomes are multiprotein complexes that detect and
                      respond to foreign and endogenous danger signals by
                      activating caspase-1; active caspase-1, in turn, matures the
                      pro-inflammatory IL-1β family cytokines by cleaving their
                      pro-forms into the biologically active cytokines. The
                      upstream mechanisms leading to inflammasome activation, in
                      particular for the NRLP3 inflammasome, remain poorly
                      understood. Lu and colleagues identify a new function of
                      Protein Kinase R (PKR) for activating the NLRP1, NLRP3,
                      NLRC4 and AIM2 inflammasomes, thus identifying a potential
                      new target for treating inflammasome-mediated diseases.},
      subtyp        = {Editorial},
      keywords     = {Animals / Carrier Proteins: metabolism / Humans /
                      Inflammasomes: metabolism / NLR Family, Pyrin
                      Domain-Containing 3 Protein / Nitric Oxide: metabolism /
                      Shock, Septic: prevention $\&$ control / Carrier Proteins
                      (NLM Chemicals) / Inflammasomes (NLM Chemicals) / NLR
                      Family, Pyrin Domain-Containing 3 Protein (NLM Chemicals) /
                      Nlrp3 protein, mouse (NLM Chemicals) / Nitric Oxide (NLM
                      Chemicals)},
      cin          = {AG Latz},
      ddc          = {570},
      cid          = {I:(DE-2719)1013024},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:22945351},
      pmc          = {pmc:PMC3567816},
      doi          = {10.1038/cr.2012.125},
      url          = {https://pub.dzne.de/record/136817},
}