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@ARTICLE{Laskowski:136915,
      author       = {Laskowski, Claudia J and Bradke, Frank},
      title        = {{I}n vivo imaging: a dynamic imaging approach to study
                      spinal cord regeneration.},
      journal      = {Experimental neurology},
      volume       = {242},
      issn         = {0014-4886},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {DZNE-2020-03237},
      pages        = {11-17},
      year         = {2013},
      abstract     = {Upon spinal cord injury, severed axons and the surrounding
                      tissue undergo a series of pathological changes, including
                      retraction of proximal axon ends, degeneration of distal
                      axon ends and formation of a dense fibrotic scar that
                      inhibits regenerative axonal growth. Until recently it was
                      technically challenging to study these dynamic events in the
                      mammalian central nervous system. Here, we describe and
                      discuss the recently established genetic tract tracing
                      approach of in vivo imaging. This technique allows studying
                      acute pathological events following a spinal cord lesion. In
                      addition, the novel development of chronic spinal cord
                      preparations such as the implanted spinal chamber now also
                      enables long-term imaging studies. Hence, in vivo imaging
                      allows the direct observation of acute and chronic dynamic
                      degenerative and regenerative events of individual neurons
                      after traumatic injury in the living animal.},
      subtyp        = {Review Article},
      keywords     = {Animals / Animals, Genetically Modified / Axons: physiology
                      / Green Fluorescent Proteins: genetics / Green Fluorescent
                      Proteins: metabolism / Neurons: pathology / Neurons:
                      physiology / Nonlinear Dynamics / Optical Imaging:
                      instrumentation / Optical Imaging: methods / Spinal Cord:
                      pathology / Spinal Cord Injuries: pathology / Spinal Cord
                      Injuries: physiopathology / Spinal Cord Regeneration:
                      physiology / Green Fluorescent Proteins (NLM Chemicals)},
      cin          = {AG Bradke},
      ddc          = {610},
      cid          = {I:(DE-2719)1013002},
      pnm          = {341 - Molecular Signaling (POF3-341)},
      pid          = {G:(DE-HGF)POF3-341},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:22836145},
      doi          = {10.1016/j.expneurol.2012.07.007},
      url          = {https://pub.dzne.de/record/136915},
}