Journal Article (Review Article)

DZNE-2020-03237

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png In vivo imaging: a dynamic imaging approach to study spinal cord regeneration.

Laskowski, C. J. (First author)DZNE* ; Bradke, F. (Last author)DZNE*

2013
Academic Press Orlando, Fla.

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Please use a persistent id in citations: doi:10.1016/j.expneurol.2012.07.007

Abstract: Upon spinal cord injury, severed axons and the surrounding tissue undergo a series of pathological changes, including retraction of proximal axon ends, degeneration of distal axon ends and formation of a dense fibrotic scar that inhibits regenerative axonal growth. Until recently it was technically challenging to study these dynamic events in the mammalian central nervous system. Here, we describe and discuss the recently established genetic tract tracing approach of in vivo imaging. This technique allows studying acute pathological events following a spinal cord lesion. In addition, the novel development of chronic spinal cord preparations such as the implanted spinal chamber now also enables long-term imaging studies. Hence, in vivo imaging allows the direct observation of acute and chronic dynamic degenerative and regenerative events of individual neurons after traumatic injury in the living animal.

Keyword(s): Animals (MeSH) ; Animals, Genetically Modified (MeSH) ; Axons: physiology (MeSH) ; Green Fluorescent Proteins: genetics (MeSH) ; Green Fluorescent Proteins: metabolism (MeSH) ; Neurons: pathology (MeSH) ; Neurons: physiology (MeSH) ; Nonlinear Dynamics (MeSH) ; Optical Imaging: instrumentation (MeSH) ; Optical Imaging: methods (MeSH) ; Spinal Cord: pathology (MeSH) ; Spinal Cord Injuries: pathology (MeSH) ; Spinal Cord Injuries: physiopathology (MeSH) ; Spinal Cord Regeneration: physiology (MeSH) ; Green Fluorescent Proteins

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Contributing Institute(s):

1. Axon Growth and Regeneration (AG Bradke)

Research Program(s):

1. 341 - Molecular Signaling (POF3-341) (POF3-341)

Appears in the scientific report 2013

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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