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000136962 0247_ $$2doi$$a10.1007/s00103-013-1767-5
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000136962 0247_ $$2ISSN$$a1436-9990
000136962 0247_ $$2ISSN$$a1437-1588
000136962 037__ $$aDZNE-2020-03284
000136962 041__ $$aGerman
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000136962 1001_ $$0P:(DE-HGF)0$$aZimmermann, T.$$b0$$eCorresponding author
000136962 245__ $$aPotenziell inadäquate Medikamente bei älteren hausärztlich versorgten Patientinnen und Patienten : Eine retrospektive Längsschnittanalyse | Potentially inappropriate medication in elderly primary care patients : A retrospective, longitudinal analysis
000136962 260__ $$aHeidelberg$$bSpringer$$c2013
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000136962 520__ $$aElderly people are often burdened by several diseases. This accounts for a higher medication intake and increases the risk of adverse drug events. To minimize this risk, several lists (Beers, PRISCUS) have been published of drugs that elderly patients should not take. We present a longitudinal analysis of the use of potentially inappropriate medication (PIM) over a period 4.5 years in a cohort of patients aged 75 years or more.Data were collected from the prospective, multicenter, observational study 'German Study on Ageing, Cognition and Dementia in Primary Care Patients (AgeCoDe),' initially enrolling 3,327 patients. We investigated the prevalence of PIM by checking medications during visits to patients' homes. Furthermore, we analyzed the use of individual PIM agents over time.At baseline, we found a PIM prevalence of 29 % according to the PRISCUS list, which decreased to 25.0 % 4.5 years later (χ(2): 7.87, p = 0.004). The Beers list yielded a prevalence of 21 % at baseline, decreasing after 4.5 years to 17.1 % (χ(2): 10.77, p = 0.000). A time-dependent multilevel model confirmed these results. Older age, depression, and the use of numerous prescribed agents are independent risk factors for using a PRISCUS-PIM.Our results seem to support a trend toward a more rational drug therapy because fewer patients were prescribed PIM. Thus, for the individual patient, the risk of adverse effects and side effects is reduced as are the costs of these effects.
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000136962 536__ $$0G:(DE-HGF)POF3-345$$a345 - Population Studies and Genetics (POF3-345)$$cPOF3-345$$fPOF III$$x1
000136962 542__ $$2Crossref$$i2013-05-29$$uhttp://www.springer.com/tdm
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000136962 650_2 $$2MeSH$$aAge Distribution
000136962 650_2 $$2MeSH$$aAged
000136962 650_2 $$2MeSH$$aAged, 80 and over
000136962 650_2 $$2MeSH$$aDepression: drug therapy
000136962 650_2 $$2MeSH$$aDepression: epidemiology
000136962 650_2 $$2MeSH$$aFemale
000136962 650_2 $$2MeSH$$aGermany: epidemiology
000136962 650_2 $$2MeSH$$aHealth Services for the Aged: statistics & numerical data
000136962 650_2 $$2MeSH$$aHealth Services for the Aged: trends
000136962 650_2 $$2MeSH$$aHumans
000136962 650_2 $$2MeSH$$aInappropriate Prescribing: statistics & numerical data
000136962 650_2 $$2MeSH$$aInappropriate Prescribing: trends
000136962 650_2 $$2MeSH$$aLongitudinal Studies
000136962 650_2 $$2MeSH$$aMale
000136962 650_2 $$2MeSH$$aPolypharmacy
000136962 650_2 $$2MeSH$$aPrimary Health Care: statistics & numerical data
000136962 650_2 $$2MeSH$$aPrimary Health Care: trends
000136962 650_2 $$2MeSH$$aRetrospective Studies
000136962 650_2 $$2MeSH$$aRisk Factors
000136962 650_2 $$2MeSH$$aSex Distribution
000136962 7001_ $$aKaduszkiewicz, H.$$b1
000136962 7001_ $$avan den Bussche, H.$$b2
000136962 7001_ $$aSchön, G.$$b3
000136962 7001_ $$aBrettschneider, C.$$b4
000136962 7001_ $$aKönig, H-H$$b5
000136962 7001_ $$aWiese, B.$$b6
000136962 7001_ $$aBickel, H.$$b7
000136962 7001_ $$aMösch, E.$$b8
000136962 7001_ $$aLuppa, M.$$b9
000136962 7001_ $$aRiedel-Heller, S.$$b10
000136962 7001_ $$aWerle, J.$$b11
000136962 7001_ $$aWeyerer, S.$$b12
000136962 7001_ $$0P:(DE-HGF)0$$aFuchs, A.$$b13
000136962 7001_ $$aPentzek, M.$$b14
000136962 7001_ $$0P:(DE-2719)2810511$$aHänisch, B.$$b15$$udzne
000136962 7001_ $$0P:(DE-2719)2000015$$aMaier, W.$$b16$$udzne
000136962 7001_ $$aScherer, M.$$b17
000136962 7001_ $$0P:(DE-2719)2000032$$aJessen, F.$$b18$$eLast author$$udzne
000136962 7001_ $$aGroup, AgeCoDe-Study$$b19
000136962 77318 $$2Crossref$$3journal-article$$a10.1007/s00103-013-1767-5$$b : Springer Science and Business Media LLC, 2013-05-29$$n7$$p941-949$$tBundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz$$v56$$x1436-9990$$y2013
000136962 773__ $$0PERI:(DE-600)1470303-8$$a10.1007/s00103-013-1767-5$$gVol. 56, no. 7, p. 941 - 949$$n7$$p941-949$$q56:7<941 - 949$$tBundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz$$v56$$x1436-9990$$y2013
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