Potenziell inadäquate Medikamente bei älteren hausärztlich versorgten Patientinnen und Patienten : Eine retrospektive Längsschnittanalyse | Potentially inappropriate medication in elderly primary care patients : A retrospective, longitudinal analysis

Zimmermann, T.; Jessen, F.; Fuchs, A.; Schön, G.; Riedel-Heller, S.; Group, AgeCoDe-Study; van den Bussche, H.; Kaduszkiewicz, H.; Weyerer, S.; Bickel, H.; Scherer, M.; Brettschneider, C.; Hänisch, B.; Pentzek, M.; König, H-H; Maier, W.; Werle, J.; Mösch, E.; Wiese, B.; Luppa, M.

doi:10.1007/s00103-013-1767-5

Journal Article

DZNE-2020-03284

Potenziell inadäquate Medikamente bei älteren hausärztlich versorgten Patientinnen und Patienten : Eine retrospektive Längsschnittanalyse | Potentially inappropriate medication in elderly primary care patients : A retrospective, longitudinal analysis

Zimmermann, T. (Corresponding author) ; Kaduszkiewicz, H. ; van den Bussche, H. ; Schön, G. ; Brettschneider, C. ; König, H.-H. ; Wiese, B. ; Bickel, H. ; Mösch, E. ; Luppa, M. ; Riedel-Heller, S. ; Werle, J. ; Weyerer, S. ; Fuchs, A. ; Pentzek, M. ; Hänisch, B.DZNE* ; Maier, W.DZNE* ; Scherer, M. ; Jessen, F. (Last author)DZNE* ; Group, A.-S.

2013
Springer Heidelberg

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz 56(7), 941-949 (2013) [10.1007/s00103-013-1767-5]

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Please use a persistent id in citations: doi:10.1007/s00103-013-1767-5

Abstract: Elderly people are often burdened by several diseases. This accounts for a higher medication intake and increases the risk of adverse drug events. To minimize this risk, several lists (Beers, PRISCUS) have been published of drugs that elderly patients should not take. We present a longitudinal analysis of the use of potentially inappropriate medication (PIM) over a period 4.5 years in a cohort of patients aged 75 years or more.Data were collected from the prospective, multicenter, observational study 'German Study on Ageing, Cognition and Dementia in Primary Care Patients (AgeCoDe),' initially enrolling 3,327 patients. We investigated the prevalence of PIM by checking medications during visits to patients' homes. Furthermore, we analyzed the use of individual PIM agents over time.At baseline, we found a PIM prevalence of 29 % according to the PRISCUS list, which decreased to 25.0 % 4.5 years later (χ(2): 7.87, p = 0.004). The Beers list yielded a prevalence of 21 % at baseline, decreasing after 4.5 years to 17.1 % (χ(2): 10.77, p = 0.000). A time-dependent multilevel model confirmed these results. Older age, depression, and the use of numerous prescribed agents are independent risk factors for using a PRISCUS-PIM.Our results seem to support a trend toward a more rational drug therapy because fewer patients were prescribed PIM. Thus, for the individual patient, the risk of adverse effects and side effects is reduced as are the costs of these effects.

Keyword(s): Age Distribution (MeSH) ; Aged (MeSH) ; Aged, 80 and over (MeSH) ; Depression: drug therapy (MeSH) ; Depression: epidemiology (MeSH) ; Female (MeSH) ; Germany: epidemiology (MeSH) ; Health Services for the Aged: statistics & numerical data (MeSH) ; Health Services for the Aged: trends (MeSH) ; Humans (MeSH) ; Inappropriate Prescribing: statistics & numerical data (MeSH) ; Inappropriate Prescribing: trends (MeSH) ; Longitudinal Studies (MeSH) ; Male (MeSH) ; Polypharmacy (MeSH) ; Primary Health Care: statistics & numerical data (MeSH) ; Primary Health Care: trends (MeSH) ; Retrospective Studies (MeSH) ; Risk Factors (MeSH) ; Sex Distribution (MeSH)