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@ARTICLE{Zimmermann:136962,
      author       = {Zimmermann, T. and Kaduszkiewicz, H. and van den Bussche,
                      H. and Schön, G. and Brettschneider, C. and König, H-H and
                      Wiese, B. and Bickel, H. and Mösch, E. and Luppa, M. and
                      Riedel-Heller, S. and Werle, J. and Weyerer, S. and Fuchs,
                      A. and Pentzek, M. and Hänisch, B. and Maier, W. and
                      Scherer, M. and Jessen, F. and Group, AgeCoDe-Study},
      title        = {{P}otenziell inadäquate {M}edikamente bei älteren
                      hausärztlich versorgten {P}atientinnen und {P}atienten :
                      {E}ine retrospektive {L}ängsschnittanalyse | {P}otentially
                      inappropriate medication in elderly primary care patients :
                      {A} retrospective, longitudinal analysis},
      journal      = {Bundesgesundheitsblatt, Gesundheitsforschung,
                      Gesundheitsschutz},
      volume       = {56},
      number       = {7},
      issn         = {1436-9990},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DZNE-2020-03284},
      pages        = {941-949},
      year         = {2013},
      abstract     = {Elderly people are often burdened by several diseases. This
                      accounts for a higher medication intake and increases the
                      risk of adverse drug events. To minimize this risk, several
                      lists (Beers, PRISCUS) have been published of drugs that
                      elderly patients should not take. We present a longitudinal
                      analysis of the use of potentially inappropriate medication
                      (PIM) over a period 4.5 years in a cohort of patients aged
                      75 years or more.Data were collected from the prospective,
                      multicenter, observational study 'German Study on Ageing,
                      Cognition and Dementia in Primary Care Patients (AgeCoDe),'
                      initially enrolling 3,327 patients. We investigated the
                      prevalence of PIM by checking medications during visits to
                      patients' homes. Furthermore, we analyzed the use of
                      individual PIM agents over time.At baseline, we found a PIM
                      prevalence of $29 \%$ according to the PRISCUS list, which
                      decreased to $25.0 \%$ 4.5 years later (χ(2): 7.87,
                      p = 0.004). The Beers list yielded a prevalence of
                      $21 \%$ at baseline, decreasing after 4.5 years to
                      $17.1 \%$ (χ(2): 10.77, p = 0.000). A time-dependent
                      multilevel model confirmed these results. Older age,
                      depression, and the use of numerous prescribed agents are
                      independent risk factors for using a PRISCUS-PIM.Our results
                      seem to support a trend toward a more rational drug therapy
                      because fewer patients were prescribed PIM. Thus, for the
                      individual patient, the risk of adverse effects and side
                      effects is reduced as are the costs of these effects.},
      keywords     = {Age Distribution / Aged / Aged, 80 and over / Depression:
                      drug therapy / Depression: epidemiology / Female / Germany:
                      epidemiology / Health Services for the Aged: statistics $\&$
                      numerical data / Health Services for the Aged: trends /
                      Humans / Inappropriate Prescribing: statistics $\&$
                      numerical data / Inappropriate Prescribing: trends /
                      Longitudinal Studies / Male / Polypharmacy / Primary Health
                      Care: statistics $\&$ numerical data / Primary Health Care:
                      trends / Retrospective Studies / Risk Factors / Sex
                      Distribution},
      cin          = {AG Hänisch / U Clinical Researchers - Bonn / AG Jessen},
      ddc          = {610},
      cid          = {I:(DE-2719)1013010 / I:(DE-2719)7000001 /
                      I:(DE-2719)1011102},
      pnm          = {344 - Clinical and Health Care Research (POF3-344) / 345 -
                      Population Studies and Genetics (POF3-345)},
      pid          = {G:(DE-HGF)POF3-344 / G:(DE-HGF)POF3-345},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:23712323},
      doi          = {10.1007/s00103-013-1767-5},
      url          = {https://pub.dzne.de/record/136962},
}