TY  - JOUR
AU  - Fell, Juergen
AU  - Staresina, Bernhard P
AU  - Do Lam, Anne T A
AU  - Widman, Guido
AU  - Helmstaedter, Christoph
AU  - Elger, Christian E
AU  - Axmacher, Nikolai
TI  - Memory modulation by weak synchronous deep brain stimulation: a pilot study.
JO  - Brain stimulation
VL  - 6
IS  - 3
SN  - 1935-861X
CY  - New York, NY [u.a.]
PB  - Elsevier
M1  - DZNE-2020-03399
SP  - 270-273
PY  - 2013
AB  - Zero-lag phase synchronization of EEG activity has been reported to be a central mechanism accompanying long-term memory formation. In this pilot study, we examined the effects of synchronous low-amplitude stimulation of the rhinal cortex and the hippocampus in eleven temporal lobe epilepsy patients. The impact of in-phase stimulation (zero lag) on long-term memory encoding of words was contrasted with anti-phase (180° phase lag) and sham stimulation. We hypothesized more correctly remembered words for the in-phase compared to the sham condition and fewer correctly remembered words for the anti-phase vs. the sham condition. Indeed, we observed a trend for a linear condition effect for correctly remembered words, which is in accordance to our prediction (in-phase > sham > anti-phase). This finding suggests that even weak synchronous deep brain stimulation of rhinal cortex and hippocampus may modulate memory performance, while clear evidence for an enhancement of memory by this kind of deep brain simulation is still lacking.
KW  - Adult
KW  - Analysis of Variance
KW  - Deep Brain Stimulation: methods
KW  - Electroencephalography
KW  - Epilepsy, Temporal Lobe: complications
KW  - Epilepsy, Temporal Lobe: therapy
KW  - Female
KW  - Humans
KW  - Magnetic Resonance Imaging
KW  - Male
KW  - Memory Disorders: etiology
KW  - Memory Disorders: therapy
KW  - Middle Aged
KW  - Neuropsychological Tests
KW  - Pilot Projects
KW  - Verbal Learning
LB  - PUB:(DE-HGF)16
C6  - pmid:22939277
DO  - DOI:10.1016/j.brs.2012.08.001
UR  - https://pub.dzne.de/record/137077
ER  -