Journal Article

DZNE-2020-03399

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Memory modulation by weak synchronous deep brain stimulation: a pilot study.

Fell, J. (Corresponding author) ; Staresina, B. P. ; Do Lam, A. T. A. ; Widman, G. ; Helmstaedter, C. ; Elger, C. E. ; Axmacher, N. (Last author)DZNE*

2013
Elsevier New York, NY [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.brs.2012.08.001

Abstract: Zero-lag phase synchronization of EEG activity has been reported to be a central mechanism accompanying long-term memory formation. In this pilot study, we examined the effects of synchronous low-amplitude stimulation of the rhinal cortex and the hippocampus in eleven temporal lobe epilepsy patients. The impact of in-phase stimulation (zero lag) on long-term memory encoding of words was contrasted with anti-phase (180° phase lag) and sham stimulation. We hypothesized more correctly remembered words for the in-phase compared to the sham condition and fewer correctly remembered words for the anti-phase vs. the sham condition. Indeed, we observed a trend for a linear condition effect for correctly remembered words, which is in accordance to our prediction (in-phase > sham > anti-phase). This finding suggests that even weak synchronous deep brain stimulation of rhinal cortex and hippocampus may modulate memory performance, while clear evidence for an enhancement of memory by this kind of deep brain simulation is still lacking.

Keyword(s): Adult (MeSH) ; Analysis of Variance (MeSH) ; Deep Brain Stimulation: methods (MeSH) ; Electroencephalography (MeSH) ; Epilepsy, Temporal Lobe: complications (MeSH) ; Epilepsy, Temporal Lobe: therapy (MeSH) ; Female (MeSH) ; Humans (MeSH) ; Magnetic Resonance Imaging (MeSH) ; Male (MeSH) ; Memory Disorders: etiology (MeSH) ; Memory Disorders: therapy (MeSH) ; Middle Aged (MeSH) ; Neuropsychological Tests (MeSH) ; Pilot Projects (MeSH) ; Verbal Learning (MeSH)

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Contributing Institute(s):

1. Fehlfunktionen des Gedächtnisses (AG Axmacher)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)

Appears in the scientific report 2013

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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