TY  - JOUR
AU  - Stamelou, Maria
AU  - Höglinger, Günter
TI  - Atypical parkinsonism: an update.
JO  - Current opinion in neurology
VL  - 26
IS  - 4
SN  - 1350-7540
CY  - [S.l.]
PB  - Ovid
M1  - DZNE-2020-03438
SP  - 401-405
PY  - 2013
AB  - This update discusses novel aspects on genetics, diagnosis, and treatments of atypical parkinsonism published over the past 2 years.A genome-wide association study identified new genetic risk factors for progressive supranuclear palsy and new genetic conditions presenting with atypical parkinsonism have been described. The clinical criteria for diagnosis of corticobasal degeneration have been revised, and for progressive supranuclear palsy are under revision. Novel molecular techniques to identify possible biomarkers, as in other neurodegenerative disorders, have started being studied on atypical parkinsonian conditions, and although preliminary results seem promising, further studies are urgently warranted. Therapeutic trials based on disease-specific targets have shown no clinical improvement.The knowledge obtained recently on atypical parkinsonian conditions points out the major deficits in this field. With the expanding phenotypical spectrum of atypical parkinsonian conditions, the early identification of patients has become difficult. The inability of conventional methods to identify these disorders earlier and better than clinicians, and the recent failure of promising therapeutic compounds, highlight the fact that the lack of biomarkers is probably the greatest limitation for developing treatments for these disorders. Thus, current and future research in this direction will be crucial.
KW  - Diagnosis, Differential
KW  - Genome-Wide Association Study
KW  - Humans
KW  - Neuroimaging
KW  - Parkinsonian Disorders: diagnosis
KW  - Parkinsonian Disorders: genetics
KW  - Parkinsonian Disorders: pathology
KW  - Risk Factors
KW  - Severity of Illness Index
KW  - Supranuclear Palsy, Progressive: diagnosis
LB  - PUB:(DE-HGF)16
C6  - pmid:23812308
C2  - pmc:PMC4196800
DO  - DOI:10.1097/WCO.0b013e3283632da6
UR  - https://pub.dzne.de/record/137116
ER  -