guest ::
| Home > Publications Database > Atypical parkinsonism: an update. |
| Home > Publications Database > Atypical parkinsonism: an update. |
| Journal Article (Review Article) | DZNE-2020-03438 |
;
2013
Ovid
[S.l.]
This record in other databases: 
Please use a persistent id in citations: doi:10.1097/WCO.0b013e3283632da6
Abstract: This update discusses novel aspects on genetics, diagnosis, and treatments of atypical parkinsonism published over the past 2 years.A genome-wide association study identified new genetic risk factors for progressive supranuclear palsy and new genetic conditions presenting with atypical parkinsonism have been described. The clinical criteria for diagnosis of corticobasal degeneration have been revised, and for progressive supranuclear palsy are under revision. Novel molecular techniques to identify possible biomarkers, as in other neurodegenerative disorders, have started being studied on atypical parkinsonian conditions, and although preliminary results seem promising, further studies are urgently warranted. Therapeutic trials based on disease-specific targets have shown no clinical improvement.The knowledge obtained recently on atypical parkinsonian conditions points out the major deficits in this field. With the expanding phenotypical spectrum of atypical parkinsonian conditions, the early identification of patients has become difficult. The inability of conventional methods to identify these disorders earlier and better than clinicians, and the recent failure of promising therapeutic compounds, highlight the fact that the lack of biomarkers is probably the greatest limitation for developing treatments for these disorders. Thus, current and future research in this direction will be crucial.
Keyword(s): Diagnosis, Differential (MeSH) ; Genome-Wide Association Study (MeSH) ; Humans (MeSH) ; Neuroimaging (MeSH) ; Parkinsonian Disorders: diagnosis (MeSH) ; Parkinsonian Disorders: genetics (MeSH) ; Parkinsonian Disorders: pathology (MeSH) ; Risk Factors (MeSH) ; Severity of Illness Index (MeSH) ; Supranuclear Palsy, Progressive: diagnosis (MeSH)
; Allianz-Lizenz ; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz
; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection
|
The record appears in these collections: |
