TY  - JOUR
AU  - Khodosevich, Konstantin
AU  - Lazarini, Françoise
AU  - Engelhardt, Jakob
AU  - Kaneko, Hiroshi
AU  - Lledo, Pierre-Marie
AU  - Monyer, Hannah
TI  - Connective tissue growth factor regulates interneuron survival and information processing in the olfactory bulb.
JO  - Neuron
VL  - 79
IS  - 6
SN  - 0896-6273
CY  - New York, NY
PB  - Elsevier
M1  - DZNE-2020-03547
SP  - 1136-1151
PY  - 2013
AB  - Neurogenesis underlies plastic changes in defined neuronal circuits in the postnatal and adult brain. Here we identify connective tissue growth factor (CTGF) as a critical factor in the mouse olfactory bulb (OB) in determining the efficiency of incorporation of postnatally born inhibitory neurons, thus gating the output of glomeruli, the first relay station of olfactory processing in the brain. In the OB, CTGF expression was restricted to prenatally born external tufted cells. CTGF enhanced the proapoptotic activity of glial-derived TGF-β2, decreasing the survival of periglomerular inhibitory neurons. Changes in CTGF expression levels in the OB led to modifications in local neuronal circuitry and olfactory behaviors. We show that the odorant-specific recruitment of distinct glomeruli resulted in enhanced local CTGF expression levels in the activated glomeruli. Collectively our data reveal a molecular mechanism controlling the survival of defined postnatally born neurons, thus adapting neuronal integration to the sensory experiences.
KW  - Analysis of Variance
KW  - Animals
KW  - Animals, Newborn
KW  - Bromodeoxyuridine: metabolism
KW  - Cell Line, Transformed
KW  - Cell Survival: genetics
KW  - Connective Tissue Growth Factor: genetics
KW  - Connective Tissue Growth Factor: metabolism
KW  - Discrimination, Psychological: physiology
KW  - Female
KW  - Gene Expression Regulation: genetics
KW  - Humans
KW  - Interneurons: physiology
KW  - Luminescent Proteins: genetics
KW  - Luminescent Proteins: metabolism
KW  - Lysine: analogs & derivatives
KW  - Lysine: metabolism
KW  - Male
KW  - Memory, Long-Term: physiology
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Mice, Transgenic
KW  - MicroRNAs: genetics
KW  - MicroRNAs: metabolism
KW  - Nerve Tissue Proteins: genetics
KW  - Nerve Tissue Proteins: metabolism
KW  - Odorants
KW  - Olfactory Bulb: cytology
KW  - Olfactory Bulb: physiology
KW  - Organ Culture Techniques
KW  - Protein-Serine-Threonine Kinases: genetics
KW  - RNA, Small Interfering: genetics
KW  - RNA, Small Interfering: metabolism
KW  - Receptor, Transforming Growth Factor-beta Type II
KW  - Receptors, Odorant: genetics
KW  - Receptors, Odorant: metabolism
KW  - Receptors, Transforming Growth Factor beta: genetics
KW  - Sensory Thresholds: physiology
KW  - Smell: genetics
KW  - Synaptic Potentials: genetics
KW  - Transfection
KW  - tau Proteins: genetics
KW  - Luminescent Proteins (NLM Chemicals)
KW  - MicroRNAs (NLM Chemicals)
KW  - Nerve Tissue Proteins (NLM Chemicals)
KW  - Olfr16 protein, mouse (NLM Chemicals)
KW  - RNA, Small Interfering (NLM Chemicals)
KW  - Receptors, Odorant (NLM Chemicals)
KW  - Receptors, Transforming Growth Factor beta (NLM Chemicals)
KW  - tau Proteins (NLM Chemicals)
KW  - Connective Tissue Growth Factor (NLM Chemicals)
KW  - Protein-Serine-Threonine Kinases (NLM Chemicals)
KW  - Receptor, Transforming Growth Factor-beta Type II (NLM Chemicals)
KW  - Bromodeoxyuridine (NLM Chemicals)
KW  - biocytin (NLM Chemicals)
KW  - Lysine (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:23993699
DO  - DOI:10.1016/j.neuron.2013.07.011
UR  - https://pub.dzne.de/record/137225
ER  -