Journal Article

DZNE-2020-03547

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Connective tissue growth factor regulates interneuron survival and information processing in the olfactory bulb.

Khodosevich, K. ; Lazarini, F. ; Engelhardt, J.DZNE* ; Kaneko, H. ; Lledo, P.-M. ; Monyer, H. (Corresponding author)

2013
Elsevier New York, NY

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Please use a persistent id in citations: doi:10.1016/j.neuron.2013.07.011

Abstract: Neurogenesis underlies plastic changes in defined neuronal circuits in the postnatal and adult brain. Here we identify connective tissue growth factor (CTGF) as a critical factor in the mouse olfactory bulb (OB) in determining the efficiency of incorporation of postnatally born inhibitory neurons, thus gating the output of glomeruli, the first relay station of olfactory processing in the brain. In the OB, CTGF expression was restricted to prenatally born external tufted cells. CTGF enhanced the proapoptotic activity of glial-derived TGF-β2, decreasing the survival of periglomerular inhibitory neurons. Changes in CTGF expression levels in the OB led to modifications in local neuronal circuitry and olfactory behaviors. We show that the odorant-specific recruitment of distinct glomeruli resulted in enhanced local CTGF expression levels in the activated glomeruli. Collectively our data reveal a molecular mechanism controlling the survival of defined postnatally born neurons, thus adapting neuronal integration to the sensory experiences.

Keyword(s): Analysis of Variance (MeSH) ; Animals (MeSH) ; Animals, Newborn (MeSH) ; Bromodeoxyuridine: metabolism (MeSH) ; Cell Line, Transformed (MeSH) ; Cell Survival: genetics (MeSH) ; Connective Tissue Growth Factor: genetics (MeSH) ; Connective Tissue Growth Factor: metabolism (MeSH) ; Discrimination, Psychological: physiology (MeSH) ; Female (MeSH) ; Gene Expression Regulation: genetics (MeSH) ; Humans (MeSH) ; Interneurons: physiology (MeSH) ; Luminescent Proteins: genetics (MeSH) ; Luminescent Proteins: metabolism (MeSH) ; Lysine: analogs & derivatives (MeSH) ; Lysine: metabolism (MeSH) ; Male (MeSH) ; Memory, Long-Term: physiology (MeSH) ; Mice (MeSH) ; Mice, Inbred C57BL (MeSH) ; Mice, Transgenic (MeSH) ; MicroRNAs: genetics (MeSH) ; MicroRNAs: metabolism (MeSH) ; Nerve Tissue Proteins: genetics (MeSH) ; Nerve Tissue Proteins: metabolism (MeSH) ; Odorants (MeSH) ; Olfactory Bulb: cytology (MeSH) ; Olfactory Bulb: physiology (MeSH) ; Organ Culture Techniques (MeSH) ; Protein-Serine-Threonine Kinases: genetics (MeSH) ; RNA, Small Interfering: genetics (MeSH) ; RNA, Small Interfering: metabolism (MeSH) ; Receptor, Transforming Growth Factor-beta Type II (MeSH) ; Receptors, Odorant: genetics (MeSH) ; Receptors, Odorant: metabolism (MeSH) ; Receptors, Transforming Growth Factor beta: genetics (MeSH) ; Sensory Thresholds: physiology (MeSH) ; Smell: genetics (MeSH) ; Synaptic Potentials: genetics (MeSH) ; Transfection (MeSH) ; tau Proteins: genetics (MeSH) ; Luminescent Proteins ; MicroRNAs ; Nerve Tissue Proteins ; Olfr16 protein, mouse ; RNA, Small Interfering ; Receptors, Odorant ; Receptors, Transforming Growth Factor beta ; tau Proteins ; Connective Tissue Growth Factor ; Protein-Serine-Threonine Kinases ; Receptor, Transforming Growth Factor-beta Type II ; Bromodeoxyuridine ; biocytin ; Lysine

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Contributing Institute(s):

1. Synaptic Signalling and Neurodegeneration (AG Engelhardt)

Research Program(s):

1. 341 - Molecular Signaling (POF3-341) (POF3-341)

Appears in the scientific report 2013

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 10 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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